The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method.
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MicroRNA-338 regulates local cytochrome c oxidase IV mRNA levels and oxidative phosphorylation in the axons of sympathetic neuronsMitophagy plays a central role in mitochondrial ageingOxidative system in aged skeletal muscleRelationship between human aging muscle and oxidative system pathwayMitochondria-ros crosstalk in the control of cell death and agingA mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicinePerformance of mitochondrial DNA mutations detecting early stage cancer.The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm.Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles.A mitochondrial etiology of Alzheimer and Parkinson diseaseSystemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia.Mitochondrial defects in neurodegenerative disease.Mitochondrial-nuclear epistasis: implications for human aging and longevity.Control region mtDNA variants: longevity, climatic adaptation, and a forensic conundrum.Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.Somatic mtDNA mutation spectra in the aging human putamen.Bioenergetic origins of complexity and disease.Mitochondrial DNA mutations in the hematopoietic system.Mitochondrial DNA as a cancer biomarkerMechanisms linking mtDNA damage and aging.Biomarkers of chondriome topology and function: implications for the extension of healthy aging.The ageing mitochondrial genomeMitochondrial DNA mutations in human colonic crypt stem cells.Mitochondrial DNA damage and the aging process: facts and imaginations.A mitochondrial bioenergetic etiology of disease.Mitochondrial DNA mutations and aging.Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replicationClinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation.The pathophysiology of mitochondrial disease as modeled in the mouse.Recurrent tissue-specific mtDNA mutations are common in humans.Mutant enrichment with 3'-modified oligonucleotides a practical PCR method for detecting trace mutant DNAs.The determination of complete human mitochondrial DNA sequences in single cells: implications for the study of somatic mitochondrial DNA point mutations.MITOMASTER: a bioinformatics tool for the analysis of mitochondrial DNA sequences.Detection of low levels of the mitochondrial tRNALeu(UUR) 3243A>G mutation in blood derived from patients with diabetes.Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with aging.Mitochondrial DNA, nuclear context, and the risk for carcinogenesis.The mitochondrial theory of aging: dead or alive?
P2860
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P2860
The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method.
description
2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
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2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The age-related accumulation o ...... ted PCR clamping based method.
@ast
The age-related accumulation o ...... ted PCR clamping based method.
@en
type
label
The age-related accumulation o ...... ted PCR clamping based method.
@ast
The age-related accumulation o ...... ted PCR clamping based method.
@en
prefLabel
The age-related accumulation o ...... ted PCR clamping based method.
@ast
The age-related accumulation o ...... ted PCR clamping based method.
@en
P2093
P2860
P356
P1476
The age-related accumulation o ...... ted PCR clamping based method.
@en
P2093
D C Wallace
D G Murdock
N C Christacos
P2860
P304
P356
10.1093/NAR/28.21.4350
P407
P577
2000-11-01T00:00:00Z