about
Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesisIn vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinoloneCharacterization of two potentially universal turn motifs that shape the repeated five-residues fold--crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142Targeting DNA topoisomerase II in cancer chemotherapyPentapeptide repeat proteinsA monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism.Focus on JNJ-Q2, a novel fluoroquinolone, for the management of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infectionsSuppression of Emergence of Resistance in Pathogenic Bacteria: Keeping Our Powder Dry, Part 1Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.The DNA relaxation activity and covalent complex accumulation of Mycobacterium tuberculosis topoisomerase I can be assayed in Escherichia coli: application for identification of potential FRET-dye labeling sites.Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure.Assessing sensitivity to antibacterial topoisomerase II inhibitors.Alterations in DNA gyrase and topoisomerase IV in resistant mutants of Clostridium perfringens found after in vitro treatment with fluoroquinolones.Single-molecule measurements of DNA topology and topoisomerases.The use of divalent metal ions by type II topoisomerases.Comparative mutant prevention concentrations of pradofloxacin and other veterinary fluoroquinolones indicate differing potentials in preventing selection of resistance.parC mutations in fluoroquinolone-resistant Borrelia burgdorferi.Arabidopsis thaliana DNA gyrase is targeted to chloroplasts and mitochondriaStructural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitorThe changing epidemiology of resistance.Short-term effect of antibiotics on human gut microbiotaReplacement of ParC alpha4 helix with that of GyrA increases the stability and cytotoxicity of topoisomerase IV-quinolone-DNA ternary complexes.A 30-years review on pharmacokinetics of antibiotics: is the right time for pharmacogenetics?Functions that Protect Escherichia coli from Tightly Bound DNA-Protein Complexes Created by Mutant EcoRII Methyltransferase.The fluoroquinolones: how long will their utility last?Moxifloxacin (Avelox): a novel fluoroquinolone with a broad spectrum of activity.Discovery of novel DNA gyrase inhibitors by high-throughput virtual screening.Topoisomerase assaysSynthesis, evaluation, and CoMFA study of fluoroquinophenoxazine derivatives as bacterial topoisomerase IA inhibitors.A fluoroquinolone resistance associated mutation in gyrA Affects DNA supercoiling in Campylobacter jejuniMutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I.Fluoroquinolone-resistant mutants of Burkholderia cepaciaFluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site.Inhibition of Mg2+ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region.Bullied no more: when and how DNA shoves proteins around.Real-time detection of DNA topological changes with a fluorescently labeled cruciform.DNA Topology and Topoisomerases: Teaching a "Knotty" Subject.Bacterial topoisomerase I as a target for discovery of antibacterial compounds.The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothingIn vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Fluoroquinolones: action and resistance.
@ast
Fluoroquinolones: action and resistance.
@en
type
label
Fluoroquinolones: action and resistance.
@ast
Fluoroquinolones: action and resistance.
@en
prefLabel
Fluoroquinolones: action and resistance.
@ast
Fluoroquinolones: action and resistance.
@en
P356
P1476
Fluoroquinolones: action and resistance.
@en
P2093
Karl Drlica
Muhammad Malik
P304
P356
10.2174/1568026033452537
P577
2003-01-01T00:00:00Z