Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes.
about
(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerasesBioflavonoids as poisons of human topoisomerase II alpha and II betaDietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancementMms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase IIInduction of unique structural changes in guanine-rich DNA regions by the triazoloacridone C-1305, a topoisomerase II inhibitor with antitumor activities.The broken MLL gene is frequently located outside the inherent chromosome territory in human lymphoid cells treated with DNA topoisomerase II poison etoposideRole of minor groove width and hydration pattern on amsacrine interaction with DNAPhosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks.A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II.Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.The use of divalent metal ions by type II topoisomerases.Efficacy of substituted 9-aminoacridine derivatives in small cell lung cancer.Dynamics of double strand breaks and chromosomal translocationsTranscription-induced DNA double strand breaks: both oncogenic force and potential therapeutic target?Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks.Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum.Unlocking and opening a DNA gate.Single-molecule measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase IIPrognostic values of filamin-A status for topoisomerase II poison chemotherapyGinkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cellsPosition-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents.DNA topoisomerase II, genotoxicity, and cancerAnalysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspectiveThe DNA cleavage reaction of topoisomerase II: wolf in sheep's clothingImpact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme.The DNA-gate of Bacillus subtilis gyrase is predominantly in the closed conformation during the DNA supercoiling reaction.Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalphaSubstituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.Quinolones: action and resistance updated.Single-molecule FRET reveals nucleotide-driven conformational changes in molecular machines and their link to RNA unwinding and DNA supercoiling.2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway.Topoisomerases: Resistance versus Sensitivity, How Far We Can Go?DNA repair protein involved in heart and blood development.Synthesis, characterization and antiproliferative activity of 1,2-naphthoquinone and its derivatives.Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II.Anti-tumour effects of xanthone derivatives and the possible mechanisms of action.D11, a novel glycosylated diphyllin derivative, exhibits potent anticancer activity by targeting topoisomerase IIα.
P2860
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P2860
Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes.
@ast
Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes.
@en
type
label
Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes.
@ast
Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes.
@en
prefLabel
Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes.
@ast
Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes.
@en
P356
P1476
Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes.
@en
P2093
Amy M Wilstermann
Neil Osheroff
P304
P356
10.2174/1568026033452519
P577
2003-01-01T00:00:00Z