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Evolution of the mitochondrial fusion-fission cycle and its role in aging

Evolution of the mitochondrial fusion-fission cycle and its role in aging

http://www.wikidata.org/entity/Q35064205

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Redox regulation of mitochondrial biogenesis Quality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity?Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions Being right on Q: shaping eukaryotic evolution The Evolution of Per-cell Organelle Number What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research Patterns of positive selection in seven ant genomes Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra What cost mitochondria? The maintenance of functional mitochondrial DNA within and across generations.Cardiac Cell Senescence and Redox Signaling.Aging leads to elevation of O-GlcNAcylation and disruption of mitochondrial homeostasis in retina.A novel role of exogenous carbon monoxide on protecting cardiac function and improving survival against sepsis via mitochondrial energetic metabolism pathway.Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells.Deceleration of fusion-fission cycles improves mitochondrial quality control during aging.Hypothalamic microinflammation: a common basis of metabolic syndrome and aging.Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion.Cardiac aging: from molecular mechanisms to significance in human health and disease Mitochondrial dysfunction in aging: Much progress but many unresolved questions.Skeletal muscle mitochondria and aging: a review.Dietary Probiotic Bacillus subtilis Strain fmbj Increases Antioxidant Capacity and Oxidative Stability of Chicken Breast Meat during Storage Natural variation in Caenorhabditis briggsae mitochondrial form and function suggests a novel model of organelle dynamics.Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging.Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes.Why did eukaryotes evolve only once? Genetic and energetic aspects of conflict and conflict mediation.Roles of mitochondrial dynamics under stressful and normal conditions in yeast cells.The systems biology of mitochondrial fission and fusion and implications for disease and aging.Mitochondrial fusion, fission, and mitochondrial toxicity.Modelling the molecular mechanisms of aging.Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases.The evolution and role of mitochondrial fusion and fission in aging and disease.What can we infer about the origin of sex in early eukaryotes?A Mitocentric View of Alzheimer's Disease.Natural selection of mitochondria during somatic lifetime promotes healthy aging.Dietary curcumin supplementation protects against heat-stress-impaired growth performance of broilers possibly through a mitochondrial pathway.Alterations in enterocyte mitochondrial respiratory function and enzyme activities in gastrointestinal dysfunction following brain injury Mitochondrial mutations and aging: random drift is insufficient to explain the accumulation of mitochondrial deletion mutants in short-lived animals.The Interaction of Mitochondrial Biogenesis and Fission/Fusion Mediated by PGC-1α Regulates Rotenone-Induced Dopaminergic Neurotoxicity.Birth of the eukaryotes by a set of reactive innovations: New insights force us to relinquish gradual models.Mitochondrial DNA density homeostasis accounts for a threshold effect in a cybrid model of a human mitochondrial disease.

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P2860

Evolution of the mitochondrial fusion-fission cycle and its role in aging

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Proceedings of the National Academy of Sciences of the United States of America

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Evolution of the mitochondrial fusion-fission cycle and its role in aging

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Axel Kowald

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Tom B L Kirkwood

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P2860

The functional organization of mitochondrial genomes in human cells

In vivo analysis of interactions between GFP-labeled microfilaments and plastid stromules.

Mitochondrial evolution

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Exchange of protein molecules through connections between higher plant plastids

The biologic clock: the mitochondria?

Mitochondrial diseases in man and mouse

Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection.

Determination of protein mobility in mitochondrial membranes of living cells.

Architecture of active mammalian respiratory chain supercomplexes.

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