μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve - Wikidata - wikimedia - TriplyDB

μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve

μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve

http://www.wikidata.org/entity/Q35064387

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Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.The hitchhiker's guide to the voltage-gated sodium channel galaxy Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity Distinct Disulfide Isomers of μ-Conotoxins KIIIA and KIIIB Block Voltage-Gated Sodium Channels Mammalian Neuronal Sodium Channel Blocker μ-Conotoxin BuIIIB Has a Structured N-Terminus That Influences Potency From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes Transient opening of the perineurial barrier for analgesic drug delivery Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.Folding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4.Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings Characterization of a novel Conus bandanus conopeptide belonging to the M-superfamily containing bromotryptophan.Molecular dynamics study of binding of µ-conotoxin GIIIA to the voltage-gated sodium channel Na(v)1.4.Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3.Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons.Systematic study of binding of μ-conotoxins to the sodium channel NaV1.4.Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics.Expanding chemical diversity of conotoxins: peptoid-peptide chimeras of the sodium channel blocker μ-KIIIA and its selenopeptide analogues Mechanism of μ-conotoxin PIIIA binding to the voltage-gated Na+ channel NaV1.4.Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ.Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA Binding modes of μ-conotoxin to the bacterial sodium channel (NaVAb)Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata.Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na(V)1.6-resurgent and persistent current.Role played by NaV 1.7 channels on thin-fiber muscle afferents in transmitting the exercise pressor reflex.Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics?Tetrodotoxin-resistant voltage-dependent sodium channels in identified muscle afferent neurons Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins.Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ.Pharmacological fractionation of tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons by μ-conotoxins Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana.An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways EXPRESS: Voltage-dependent sodium (NaV) channels in group IV sensory afferents.Neuronal Na+ Channels Are Integral Components of Pro-arrhythmic Na+/Ca2+ Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-adrenergic Stimulation.A Novel Striated Muscle-Specific Myosin-Blocking Drug for the Study of Neuromuscular Physiology.A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons.Animal toxins influence voltage-gated sodium channel function.Therapeutic conotoxins: a US patent literature survey.Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study.

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P2860

μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve

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2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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μ-Conotoxins that differential ...... on potentials in sciatic nerve

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μ-Conotoxins that differential ...... on potentials in sciatic nerve

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μ-Conotoxins that differential ...... on potentials in sciatic nerve

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μ-Conotoxins that differential ...... on potentials in sciatic nerve

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μ-Conotoxins that differential ...... on potentials in sciatic nerve

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Proceedings of the National Academy of Sciences of the United States of America

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μ-Conotoxins that differential ...... on potentials in sciatic nerve

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Baldomero M Olivera

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Doju Yoshikami

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Grzegorz Bulaj

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Joanna Gajewiak

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Layla Azam

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Michael J Wilson

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Min-Min Zhang

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P2860

A quantitative description of membrane current and its application to conduction and excitation in nerve

Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxin

Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses

TETRODOTOXIN BLOCKAGE OF SODIUM CONDUCTANCE INCREASE IN LOBSTER GIANT AXONS

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

Sodium channel beta subunits: anything but auxiliary

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels

A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons.

Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus

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