Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein
about
Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivationTargeting Th17 Cells with Small Molecules and Small Interference RNAAdvances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple SclerosisROR nuclear receptors: structures, related diseases, and drug discoveryThe therapeutic potential of RORγ modulators in the treatment of human diseaseSterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonistsIdentification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell DifferentiationDevelopment of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to SkinIdentification of an allosteric binding site for RORγt inhibition.Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-ATAction of RORs and their ligands in (patho)physiology.Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.REV-ERB and ROR nuclear receptors as drug targets.Small molecule amides as potent ROR-γ selective modulators.Concise review: chemical approaches for modulating lineage-specific stem cells and progenitors.Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunityIdentification of SR2211: a potent synthetic RORγ-selective modulator.Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivityRetinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism.Metabolic control of the Treg/Th17 axisMolecular Targets for Small-Molecule Modulators of Circadian Clocks.Therapeutic antibodies that target inflammatory cytokines in autoimmune diseasesHighlights of 10 years of immunology in Nature Reviews Immunology.Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors.Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.Discovery and structural optimization of 4-(4-(benzyloxy)phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists.Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritisSuppression of muscle wasting by the plant-derived compound ursolic acid in a model of chronic kidney disease.Targeting the Th17 pathway in psoriasis.Yin-Yang Regulation of RORγt Protein Complex in Th17 Differentiation.Th17 cells in autoimmune diseases.In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists.Identification of a selective RORγ ligand that suppresses T(H)17 cells and stimulates T regulatory cells.Harnessing the Therapeutic Potential of Th17 Cells.Ursolic Acid--A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities.CYP19A1, MIF and ABCA1 genes are targets of the RORα in monocyte and endothelial cells.Synthesis of dihydroimidazole tethered imidazolinethiones and their activity as novel antagonists of the nuclear retinoic acid receptor-related orphan receptors (RORs).The IL-17-Th1/Th17 pathway: an attractive target for lung cancer therapy?Ursolic acid, a potential anticancer compound for breast cancer therapy.
P2860
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P2860
Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Ursolic acid suppresses interl ...... function of RORgamma t protein
@ast
Ursolic acid suppresses interl ...... function of RORgamma t protein
@en
type
label
Ursolic acid suppresses interl ...... function of RORgamma t protein
@ast
Ursolic acid suppresses interl ...... function of RORgamma t protein
@en
prefLabel
Ursolic acid suppresses interl ...... function of RORgamma t protein
@ast
Ursolic acid suppresses interl ...... function of RORgamma t protein
@en
P2093
P2860
P356
P1476
Ursolic acid suppresses interl ...... function of RORgamma t protein
@en
P2093
P2860
P304
22707-22710
P356
10.1074/JBC.C111.250407
P407
P577
2011-05-12T00:00:00Z