Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma
about
ROR nuclear receptors: structures, related diseases, and drug discoveryThe therapeutic potential of RORγ modulators in the treatment of human diseaseStructural Basis of Digoxin That Antagonizes ROR t Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 ProductionStructural insights into gene repression by the orphan nuclear receptor SHPBenzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγFragment Screening of RORγt Using Cocktail Crystallography: Identification of Simultaneous Binding of Multiple FragmentsMolecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonistsTherapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of AutismRORγ directly regulates the circadian expression of clock genes and downstream targets in vivoIdentification of an allosteric binding site for RORγt inhibition.Retinoic acid actions through mammalian nuclear receptors.LDL cholesterol modulates human CD34+ HSPCs through effects on proliferation and the IL-17 G-CSF axisRORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes.Action of RORs and their ligands in (patho)physiology.Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases.Structural and functional insights into nuclear receptor signaling.REV-ERB and ROR nuclear receptors as drug targets.Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ.Nuclear hormone receptors put immunity on sterols.VP40 of the Ebola Virus as a Target for EboV Therapy: Comprehensive Conformational and Inhibitor Binding Landscape from Accelerated Molecular Dynamics.Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonistRetinoic acid-related orphan receptor γ directly regulates neuronal PAS domain protein 2 transcription in vivo.Identification of natural RORγ ligands that regulate the development of lymphoid cellsUrsolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t proteinThe REV-ERBs and RORs: molecular links between circadian rhythms and lipid homeostasis.Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligandDigoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activityTargeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunityIdentification of SR2211: a potent synthetic RORγ-selective modulator.Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell PathogenicityRetinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivityRetinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism.Segregation of Clock and Non-Clock Regulatory Functions of REV-ERB.Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspectiveIdentification of Potent and Selective Diphenylpropanamide RORγ Inhibitors.
P2860
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P2860
Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Structural basis for hydroxych ...... phan nuclear receptor RORgamma
@ast
Structural basis for hydroxych ...... phan nuclear receptor RORgamma
@en
Structural basis for hydroxych ...... phan nuclear receptor RORgamma
@en-gb
Structural basis for hydroxych ...... phan nuclear receptor RORgamma
@nl
type
label
Structural basis for hydroxych ...... phan nuclear receptor RORgamma
@ast
Structural basis for hydroxych ...... phan nuclear receptor RORgamma
@en
Structural basis for hydroxych ...... phan nuclear receptor RORgamma
@en-gb
Structural basis for hydroxych ...... phan nuclear receptor RORgamma
@nl
altLabel
Structural Basis for Hydroxych ...... f Orphan Nuclear Receptor RORγ
@en
prefLabel
Structural basis for hydroxych ...... phan nuclear receptor RORgamma
@ast
Structural basis for hydroxych ...... phan nuclear receptor RORgamma
@en
Structural basis for hydroxych ...... phan nuclear receptor RORgamma
@en-gb
Structural basis for hydroxych ...... phan nuclear receptor RORgamma
@nl
P2093
P2860
P3181
P356
P1476
Structural basis for hydroxych ...... phan nuclear receptor RORgamma
@en
P2093
Dariusz Martynowski
Songyang Zheng
Taira Wada
P2860
P304
P3181
P356
10.1210/ME.2009-0507
P407
P50
P577
2010-03-04T00:00:00Z