Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors
about
Atomic-Resolution Structures of Horse Liver Alcohol Dehydrogenase with NAD + and Fluoroalcohols Define Strained Michaelis ComplexesDynamically achieved active site precision in enzyme catalysisEffects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reactionPicosecond-resolved fluorescent probes at functionally distinct tryptophans within a thermophilic alcohol dehydrogenase: relationship of temperature-dependent changes in fluorescence to catalysis.Hydrogen tunneling links protein dynamics to enzyme catalysisImportance of protein dynamics during enzymatic C-H bond cleavage catalysis.Picosecond-resolved fluorescence studies of substrate and cofactor-binding domain mutants in a thermophilic alcohol dehydrogenase uncover an extended network of communication.Evolutionary aspects of enzyme dynamicsDynamics differentiate between active and inactive inteins.Multiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase.Kinetic Detection of Orthogonal Protein and Chemical Coordinates in Enzyme Catalysis: Double Mutants of Soybean Lipoxygenase.Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures.Tuned by metals: the TET peptidase activity is controlled by 3 metal binding sites.Identification of a long-range protein network that modulates active site dynamics in extremophilic alcohol dehydrogenases.Connecting protein conformational dynamics with catalytic function as illustrated in dihydrofolate reductase.Interdomain long-range electron transfer becomes rate-limiting in the Y216A variant of tyramine β-monooxygenase.Hydrogen tunneling in a prokaryotic lipoxygenase.Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling.Hydrostatic Pressure Studies Distinguish Global from Local Protein Motions in C-H Activation by Soybean Lipoxygenase-1.Temperature-Jump Fluorescence Provides Evidence for Fully Reversible Microsecond Dynamics in a Thermophilic Alcohol Dehydrogenase.Hydrogen donor-acceptor fluctuations from kinetic isotope effects: a phenomenological model.A conserved P-loop anchor limits the structural dynamics that mediate nucleotide dissociation in EF-Tu.Enhanced Rigidification within a Double Mutant of Soybean Lipoxygenase Provides Experimental Support for Vibronically Nonadiabatic Proton-Coupled Electron Transfer Models.Relaxation of nonproductive binding and increased rate of coenzyme release in an alcohol dehydrogenase increases turnover with a nonpreferred alcohol enantiomer.Kinetics of low-temperature transitions and a reaction rate theory from non-equilibrium distributions.Activity-Related Microsecond Dynamics Revealed by Temperature-Jump Förster Resonance Energy Transfer Measurements on Thermophilic Alcohol Dehydrogenase.Engineered control of enzyme structural dynamics and function.
P2860
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P2860
Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors
@ast
Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors
@en
type
label
Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors
@ast
Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors
@en
prefLabel
Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors
@ast
Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors
@en
P2093
P2860
P356
P1476
Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors
@en
P2093
Brian J Bahnson
Judith P Klinman
Zachary D Nagel
P2860
P304
10520-10525
P356
10.1073/PNAS.1104989108
P407
P577
2011-06-13T00:00:00Z