Hydrogen tunneling links protein dynamics to enzyme catalysis
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The Use of Multiscale Molecular Simulations in Understanding a Relationship between the Structure and Function of Biological Systems of the Brain: The Application to Monoamine Oxidase EnzymesDynamic behavior of rearranging carbocations - implications for terpene biosynthesisDihydrofolate reductase as a model for studies of enzyme dynamics and catalysisPerspectives on electrostatics and conformational motions in enzyme catalysisBiochemistry and theory of proton-coupled electron transferRole of substrate dynamics in protein prenylation reactionsEffects of Cavities at the Nicotinamide Binding Site of Liver Alcohol Dehydrogenase on Structure, Dynamics and CatalysisExtremely Elevated Room-Temperature Kinetic Isotope Effects Quantify the Critical Role of Barrier Width in Enzymatic C–H ActivationDynamically achieved active site precision in enzyme catalysisThe importance of ensemble averaging in enzyme kineticsPreservation of protein dynamics in dihydrofolate reductase evolutionHow Large Should the QM Region Be in QM/MM Calculations? The Case of Catechol O-MethyltransferaseDoes the pressure dependence of kinetic isotope effects report usefully on dynamics in enzyme H-transfer reactions?Perspective: Defining and quantifying the role of dynamics in enzyme catalysisEffects of protein structure on iron-polypeptide vibrational dynamic coupling in cytochrome c.Incorporating modeling and simulations in undergraduate biophysical chemistry course to promote understanding of structure-dynamics-function relationships in proteins.Convergent Mechanistic Features between the Structurally Diverse N- and O-Methyltransferases: Glycine N-Methyltransferase and Catechol O-Methyltransferase.Mechanism of Flavoprotein l-6-Hydroxynicotine Oxidase: pH and Solvent Isotope Effects and Identification of Key Active Site Residues.Picosecond-resolved fluorescent probes at functionally distinct tryptophans within a thermophilic alcohol dehydrogenase: relationship of temperature-dependent changes in fluorescence to catalysis.Importance of protein dynamics during enzymatic C-H bond cleavage catalysis.Yeast alcohol dehydrogenase structure and catalysis.Evolutionary aspects of enzyme dynamicsEscherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: temporal order and the roles of Asp27 and Tyr100.Quantum delocalization of protons in the hydrogen-bond network of an enzyme active site.The energy landscape of adenylate kinase during catalysis.Role of dynamics in enzyme catalysis: substantial versus semantic controversies.Kinetic Detection of Orthogonal Protein and Chemical Coordinates in Enzyme Catalysis: Double Mutants of Soybean Lipoxygenase.Protein-like proton exchange in a synthetic host cavity.Competition H(D) kinetic isotope effects in the autoxidation of hydrocarbonsLigand-Dependent Conformational Dynamics of Dihydrofolate Reductase.Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.A New Spin on Neural Processing: Quantum Cognition.Kinetic isotope effects as a probe of hydrogen transfers to and from common enzymatic cofactorsHydrogen tunneling in enzymes and biomimetic models.The power of integrating kinetic isotope effects into the formalism of the Michaelis-Menten equation.Protein motions and the activation of the CH bond catalyzed by dihydrofolate reductase.Applications of quantum mechanical/molecular mechanical methods to the chemical insertion step of DNA and RNA polymerization.Linking protein motion to enzyme catalysis.Fabrication of solid-state nanopores and its perspectives.Computational replication of the abnormal secondary kinetic isotope effects in a hydride transfer reaction in solution with a motion assisted H-tunneling model.
P2860
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P2860
Hydrogen tunneling links protein dynamics to enzyme catalysis
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Hydrogen tunneling links protein dynamics to enzyme catalysis
@ast
Hydrogen tunneling links protein dynamics to enzyme catalysis
@en
type
label
Hydrogen tunneling links protein dynamics to enzyme catalysis
@ast
Hydrogen tunneling links protein dynamics to enzyme catalysis
@en
prefLabel
Hydrogen tunneling links protein dynamics to enzyme catalysis
@ast
Hydrogen tunneling links protein dynamics to enzyme catalysis
@en
P2860
P1476
Hydrogen tunneling links protein dynamics to enzyme catalysis
@en
P2093
Amnon Kohen
Judith P Klinman
P2860
P304
P356
10.1146/ANNUREV-BIOCHEM-051710-133623
P577
2013-01-01T00:00:00Z