Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease - Wikidata - wikimedia - TriplyDB

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

http://www.wikidata.org/entity/Q35084110

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The generation and function of soluble apoE receptors in the CNS Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease Alzheimer's disease as homeostatic responses to age-related myelin breakdown Alzheimer mechanisms and therapeutic strategies Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22.Impact of apolipoprotein E on Alzheimer's disease Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling Enhancing CNS repair in neurological disease: challenges arising from neurodegeneration and rewiring of the network Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1 Similar promotion of Abeta1-42 fibrillogenesis by native apolipoprotein E epsilon3 and epsilon4 isoforms The amyloid hypothesis of Alzheimer's disease at 25 years Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1 Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease Towards understanding the roles of heparan sulfate proteoglycans in Alzheimer's disease Oxidized cholesterol as the driving force behind the development of Alzheimer's disease HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease.HSV-1 and Alzheimer's disease: more than a hypothesis.Is ApoE ɛ 4 a good biomarker for amyloid pathology in late onset Alzheimer's disease?Neuropsychiatric Disturbances in Alzheimer's Disease: What Have We Learned from Neuropathological Studies?ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives Structural basis for the recognition and cross-linking of amyloid fibrils by human apolipoprotein E The pathogenic implication of abnormal interaction between apolipoprotein E isoforms, amyloid-beta peptides, and sulfatides in Alzheimer's disease Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes In vivo human apolipoprotein E isoform fractional turnover rates in the CNS Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation.PET amyloid-beta imaging in preclinical Alzheimer's disease The Neurobiology and Age-Related Prevalence of the ε4 Allele of Apolipoprotein E in Alzheimer's Disease Cohorts.

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

http://www.wikidata.org/entity/Q35084110

description

2000 nî lūn-bûn

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2000 թուականի Մարտին հրատարակուած գիտական յօդուած

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2000 թվականի մարտին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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Apolipoprotein E isoform-depen ...... e model of Alzheimer's disease

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Proceedings of the National Academy of Sciences of the United States of America

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Apolipoprotein E isoform-depen ...... e model of Alzheimer's disease

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A M Fagan

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B Mackey

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D M Holtzman

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D McKeel

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D Wozniak

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J Olney

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K R Bales

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L J Sartorius

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M Parsadanian

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S M Paul

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P2860

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

Isoform-specific binding of apolipoprotein E to beta-amyloid

Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease.

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.

Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease.

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

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2892-2897

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10.1073/PNAS.050004797

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6

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97

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2000-03-01T00:00:00Z

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12620234

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10694577

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Alzheimer's disease

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16026

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