4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth.
about
Legionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp-type phosphopantetheinyl transferaseBreaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategyPost-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.A Platform to Enable the Pharmacological Profiling of Small Molecules in Gel-Based Electrophoretic Mobility Shift Assays.The Structure-Antimicrobial Activity Relationships of a Promising Class of the Compounds Containing the N-Arylpiperazine Scaffold.Sfp-type PPTase inactivation promotes bacterial biofilm formation and ability to enhance wheat drought tolerance.A Chemoproteomics Approach to Investigate Phosphopantetheine Transferase Activity at the Cellular Level.Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies
P2860
Q28818404-C5E4267B-A5E3-4EEC-A7BC-9C84A649F67FQ35688927-6EC6B44A-5F16-4F0E-8C66-6CC3FAA54900Q35759485-1A0B8018-52DD-40EA-B095-25C92A0E0596Q35998002-4DE02EF1-5B78-46F4-9279-EAAC73B5708EQ36043040-BD876523-F4BE-4A25-9EC5-0C307323D6FBQ38743289-B3E05EE7-BF03-4AA0-BB4A-CF3C48506FF1Q39525209-0013F2F8-3C3C-466D-BB34-BFD69CCD5EF4Q48103865-50AD55C7-9657-4F7B-9874-3C7847028C05Q52648182-CEED828C-C9FE-4266-8851-9773FE017BAFQ58692742-D2F475D0-29D9-47BC-8499-B908B92F8DFA
P2860
4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth.
description
2014 nî lūn-bûn
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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
4-(3-Chloro-5-(trifluoromethyl ...... and thwarts bacterial growth.
@ast
4-(3-Chloro-5-(trifluoromethyl ...... and thwarts bacterial growth.
@en
type
label
4-(3-Chloro-5-(trifluoromethyl ...... and thwarts bacterial growth.
@ast
4-(3-Chloro-5-(trifluoromethyl ...... and thwarts bacterial growth.
@en
prefLabel
4-(3-Chloro-5-(trifluoromethyl ...... and thwarts bacterial growth.
@ast
4-(3-Chloro-5-(trifluoromethyl ...... and thwarts bacterial growth.
@en
P2093
P2860
P50
P356
P1476
4-(3-Chloro-5-(trifluoromethyl ...... and thwarts bacterial growth.
@en
P2093
David J Maloney
Ganesha Rai
Heather L Baker
Matias Attene-Ramos
Michael D Burkart
Nicolas M Kosa
Thomas Daniel
Timothy L Foley
William Leister
P2860
P304
P356
10.1021/JM401752P
P407
P577
2014-01-22T00:00:00Z