Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation
about
Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosisMechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesisPapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosisProduction of mycobacterial cell wall glycopeptidolipids requires a member of the MbtH-like protein familyA high-throughput screening fluorescence polarization assay for fatty acid adenylating enzymes in Mycobacterium tuberculosis.Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide-polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis.Biochemical and genetic insights into asukamycin biosynthesis.The mycobacterial cell envelope-lipidsThe cell envelope glycoconjugates of Mycobacterium tuberculosisAssay development for identifying inhibitors of the mycobacterial FadD32 activity.General platform for systematic quantitative evaluation of small-molecule permeability in bacteria.Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids.4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth.Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum.Inactivation of tesA reduces cell wall lipid production and increases drug susceptibility in mycobacteria.Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of PseudonocardiaceaeBoth phthiocerol dimycocerosates and phenolic glycolipids are required for virulence of Mycobacterium marinum.Comparative Genomic Analysis Reveals a Possible Novel Non-Tuberculous Mycobacterium Species with High Pathogenic Potential.Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosaNatural products as mediators of disease.Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesisPleiotropic consequences of gene knockouts in the phthiocerol dimycocerosate and phenolic glycolipid biosynthetic gene cluster of the opportunistic human pathogen Mycobacterium marinumF420H2 Is Required for Phthiocerol Dimycocerosate Synthesis in Mycobacteria.Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy.Adenylating enzymes in Mycobacterium tuberculosis as drug targets.Targeting the mycobacterial envelope for tuberculosis drug development.Biosynthesis of mycobacterial lipids by polyketide synthases and beyond.Mutational and phylogenetic analyses of the mycobacterial mbt gene cluster.Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases.Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestisCooperation between a coenzyme A-independent stand-alone initiation module and an iterative type I polyketide synthase during synthesis of mycobacterial phenolic glycolipids.Cyclic AMP-dependent protein lysine acylation in mycobacteria regulates fatty acid and propionate metabolism.A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase.The mycobacterial acyltransferase PapA5 is required for biosynthesis of cell wall-associated phenolic glycolipidsPreparation of FRET reporters to support chemical probe development.Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes.
P2860
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P2860
Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation
description
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
scientific journal article
@en
vedecký článok (publikovaný 2008/01/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/01/01)
@nl
наукова стаття, опублікована в січні 2008
@uk
مقالة علمية (نشرت عام 2008)
@ar
name
Mycobacterial phenolic glycoli ...... of polyketide chain initiation
@ast
Mycobacterial phenolic glycoli ...... of polyketide chain initiation
@en
Mycobacterial phenolic glycoli ...... of polyketide chain initiation
@nl
type
label
Mycobacterial phenolic glycoli ...... of polyketide chain initiation
@ast
Mycobacterial phenolic glycoli ...... of polyketide chain initiation
@en
Mycobacterial phenolic glycoli ...... of polyketide chain initiation
@nl
prefLabel
Mycobacterial phenolic glycoli ...... of polyketide chain initiation
@ast
Mycobacterial phenolic glycoli ...... of polyketide chain initiation
@en
Mycobacterial phenolic glycoli ...... of polyketide chain initiation
@nl
P2093
P2860
P3181
P1476
Mycobacterial phenolic glycoli ...... of polyketide chain initiation
@en
P2093
Clifford E. Soll
Derek S. Tan
Jae-Sang Ryu
Julian A. Ferreras
Karen L. Stirrett
Luis E. N. Quadri
Xuequan Lu
P2860
P3181
P356
10.1016/J.CHEMBIOL.2007.11.010
P577
2008-01-01T00:00:00Z