Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.
about
The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-cateninBrk/PTK6 signaling in normal and cancer cell models.Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRKHIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.Constitutive activation of breast tumor kinase accelerates cell migration and tumor growth in vivo.Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis.Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer.Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis.Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma.Overexpression of PTK6 predicts poor prognosis in bladder cancer patients.
P2860
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P2860
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.
description
2006 nî lūn-bûn
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2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
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name
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.
@ast
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.
@en
type
label
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.
@ast
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.
@en
prefLabel
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.
@ast
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.
@en
P2093
P2860
P1476
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes
@en
P2093
Andrzej Ptasznik
Maria Wysocka
Mariusz A Wasik
Mark R Crompton
Miroslaw Majewski
Monika Kasprzycka
Phyllis Gimotty
Qian Zhang
Zhi-Jong Wang
P2860
P304
P356
10.2353/AJPATH.2006.050521
P407
P577
2006-05-01T00:00:00Z