Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours
about
Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding abilitySignal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillinMolecular cloning and characterization of PTP pi, a novel receptor-like protein-tyrosine phosphataseSignal transducer and activator of transcription 3 regulation by novel binding partnersProtein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrateProtein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factorBrk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor KinaseProtein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestineCancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.Low expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma.The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-cateninThe marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling.The associated pyrazolopyrimidines PP1 and PP2 inhibit protein tyrosine kinase 6 activity and suppress breast cancer cell proliferation.PTK6 regulates IGF-1-induced anchorage-independent survival.Brk/PTK6 signaling in normal and cancer cell models.Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRKEvolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapyMechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rakCytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells.Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.Sphingosine-1-phosphate induces the migration of thyroid follicular carcinoma cells through the microRNA-17/PTK6/ERK1/2 pathwayPTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling.Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFRSuppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin.Constitutive activation of breast tumor kinase accelerates cell migration and tumor growth in vivo.PTK (protein tyrosine kinase)-6 and HER2 and 4, but not HER1 and 3 predict long-term survival in breast carcinomas.Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition.
P2860
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P2860
Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours
description
1994 nî lūn-bûn
@nan
1994 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Cloning and characterisation o ...... ressed in human breast tumours
@ast
Cloning and characterisation o ...... ressed in human breast tumours
@en
Cloning and characterisation o ...... ressed in human breast tumours
@en-gb
Cloning and characterisation o ...... ressed in human breast tumours
@nl
type
label
Cloning and characterisation o ...... ressed in human breast tumours
@ast
Cloning and characterisation o ...... ressed in human breast tumours
@en
Cloning and characterisation o ...... ressed in human breast tumours
@en-gb
Cloning and characterisation o ...... ressed in human breast tumours
@nl
prefLabel
Cloning and characterisation o ...... ressed in human breast tumours
@ast
Cloning and characterisation o ...... ressed in human breast tumours
@en
Cloning and characterisation o ...... ressed in human breast tumours
@en-gb
Cloning and characterisation o ...... ressed in human breast tumours
@nl
P2093
P3181
P1433
P1476
Cloning and characterisation o ...... ressed in human breast tumours
@en
P2093
Crompton MR
Gusterson BA
Kamalati T
Martindale JE
Mitchell PJ
P304
P3181
P407
P577
1994-08-01T00:00:00Z