The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome.
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Cloning and characterization of a novel human SPRYD4 gene encoding a putative SPRY domain-containing proteinActive transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2AStructural and functional insights into the B30.2/SPRY domain.TRIM family proteins and their emerging roles in innate immunityMig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubulesAdaptive responses of androgen receptor signaling in castration-resistant prostate cancerThe biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificityNMR studies of the C-terminus of alpha4 reveal possible mechanism of its interaction with MID1 and protein phosphatase 2ACsf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice.XLOS-observed mutations of MID1 Bbox1 domain cause domain unfolding.The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus.The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila.Control of mTORC1 signaling by the Opitz syndrome protein MID1.MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.Midline 1 controls polarization and migration of murine cytotoxic T cells.Molecular dynamics simulation reveals insights into the mechanism of unfolding by the A130T/V mutations within the MID1 zinc-binding Bbox1 domain.The MID1 E3 ligase catalyzes the polyubiquitination of Alpha4 (α4), a regulatory subunit of protein phosphatase 2A (PP2A): novel insights into MID1-mediated regulation of PP2A.A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction.A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signalingProtein phosphatase 2A (PP2A)-specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent protein kinase-1 (PDPK-1).Protein phosphatase 2A plays an important role in migration of bone marrow stroma cells.Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity.Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells.The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex.Two Novel Pathogenic MID1 Variants and Genotype-Phenotype Correlation Reanalysis in X-Linked Opitz G/BBB Syndrome.Structural and functional observations of the P151L MID1 mutation reveal alpha4 plays a significant role in X-linked Opitz Syndrome.Midline 1 directs lytic granule exocytosis and cytotoxicity of mouse killer T cells.MID2 can substitute for MID1 and control exocytosis of lytic granules in cytotoxic T cells
P2860
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P2860
The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome.
description
2003 nî lūn-bûn
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2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2003 թվականի ապրիլին հրատարակված գիտական հոդված
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2003年の論文
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2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
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2003年论文
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name
The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome.
@ast
The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome.
@en
type
label
The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome.
@ast
The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome.
@en
prefLabel
The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome.
@ast
The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome.
@en
P356
P1433
P1476
The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome.
@en
P2093
Rainer Schneider
Susann Schweiger
P304
P356
10.1002/BIES.10256
P407
P577
2003-04-01T00:00:00Z