Role of dynamics in enzyme catalysis: substantial versus semantic controversies.
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Dihydrofolate reductase as a model for studies of enzyme dynamics and catalysisLigand Binding Enhances Millisecond Conformational Exchange in Xylanase B2 from Streptomyces lividansPerspective: Defining and quantifying the role of dynamics in enzyme catalysisConservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics.Structural and Kinetic Studies of Formate Dehydrogenase from Candida boidinii.Isotope-specific and amino acid-specific heavy atom substitutions alter barrier crossing in human purine nucleoside phosphorylasePerturbation of the Conformational Dynamics of an Active-Site Loop Alters Enzyme ActivityRole of Loop-Clamping Side Chains in Catalysis by Triosephosphate Isomerase.Whither Enzymology in the Twenty First Century?Linking protein motion to enzyme catalysis.Hydride Transfer in DHFR by Transition Path Sampling, Kinetic Isotope Effects, and Heavy Enzyme StudiesThe Effect of Protein Mass Modulation on Human Dihydrofolate Reductase.Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate.Atom Tunneling in Chemistry.Oscillatory Enzyme Dynamics Revealed by Two-Dimensional Infrared Spectroscopy.Electric Fields and Enzyme Catalysis.Preserved hydride transfer mechanism in evolutionarily divergent thymidylate synthases.Probing reversible chemistry in coenzyme B12 -dependent ethanolamine ammonia lyase with kinetic isotope effects.Network of remote and local protein dynamics in dihydrofolate reductase catalysisActivation of Two Sequential H-transfers in the Thymidylate Synthase Catalyzed Reaction.Examinations of the Chemical Step in Enzyme Catalysis.The role of protein dynamics in allosteric effects-introduction.Are there dynamical effects in enzyme catalysis? Some thoughts concerning the enzymatic chemical step.The general base in the thymidylate synthase catalyzed proton abstraction.Protonation-Initiated Cyclization by a Class II Terpene Cyclase Assisted by Tunneling.Contribution of Buried Distal Amino Acid Residues in Horse Liver Alcohol Dehydrogenase to Structure and Catalysis.Electric Fields and Fast Protein Dynamics in Enzymes.Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase.Protein dynamics promote hydride tunnelling in substrate oxidation by aryl-alcohol oxidase.Incorporating Fast Protein Dynamics into Enzyme Design: A Proposed Mutant Aromatic Amine Dehydrogenase.Free-Energy Landscape and Proton Transfer Pathways in Oxidative Deamination by Methylamine Dehydrogenase.Two Dynamical Regimes of the Substrate Radical Rearrangement Reaction in B12-Dependent Ethanolamine Ammonia-Lyase Resolve Contributions of Native Protein Configurations and Collective Configurational Fluctuations to Catalysis.Benchmarking Quantum Mechanics/Molecular Mechanics (QM/MM) Methods on the Thymidylate Synthase-Catalyzed Hydride Transfer.Engineered control of enzyme structural dynamics and function.Changes in dynamics of α-chymotrypsin due to covalent inhibitors investigated by elastic incoherent neutron scattering.Role of Conformational Motions in Enzyme Function: Selected Methodologies and Case Studies.The role of the Met20 loop in the hydride transfer in Escherichia coli dihydrofolate reductase.Promoting Vibrations and the Function of Enzymes. Emerging Theoretical and Experimental Convergence.Conservation of Dynamics Associated with Biological Function in an Enzyme Superfamily.Bacterial versus human thymidylate synthase: Kinetics and functionality.
P2860
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P2860
Role of dynamics in enzyme catalysis: substantial versus semantic controversies.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Role of dynamics in enzyme catalysis: substantial versus semantic controversies.
@ast
Role of dynamics in enzyme catalysis: substantial versus semantic controversies.
@en
type
label
Role of dynamics in enzyme catalysis: substantial versus semantic controversies.
@ast
Role of dynamics in enzyme catalysis: substantial versus semantic controversies.
@en
prefLabel
Role of dynamics in enzyme catalysis: substantial versus semantic controversies.
@ast
Role of dynamics in enzyme catalysis: substantial versus semantic controversies.
@en
P2860
P356
P1476
Role of dynamics in enzyme catalysis: substantial versus semantic controversies.
@en
P2093
Amnon Kohen
P2860
P304
P356
10.1021/AR500322S
P577
2014-12-24T00:00:00Z
2015-02-17T00:00:00Z