Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. - Wikidata - wikimedia - TriplyDB

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.

http://www.wikidata.org/entity/Q35101307

about

MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter Posttranscriptional control of T cell effector function by aerobic glycolysis Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans The Warburg effect: 80 years on ATP13A2 regulates mitochondrial bioenergetics through macroautophagy A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype Bioenergetic profiling of zebrafish embryonic development Differential mitochondrial toxicity screening and multi-parametric data analysis Pathway analysis reveals common pro-survival mechanisms of metyrapone and carbenoxolone after traumatic brain injury MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia Revisiting Kadenbach: Electron flux rate through cytochrome c-oxidase determines the ATP-inhibitory effect and subsequent production of ROS Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer Mitochondrial dysfunction remodels one-carbon metabolism in human cells Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation.Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility.A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans.Mitochondrial Transfer from Wharton's Jelly Mesenchymal Stem Cell to MERRF Cybrid Reduces Oxidative Stress and Improves Mitochondrial Bioenergetics.A pairwise chemical genetic screen identifies new inhibitors of glucose transport.Antioxidant supplement inhibits skeletal muscle constitutive autophagy rather than fasting-induced autophagy in mice.Impaired mitochondrial function in human placenta with increased maternal adiposity A cell-based phenotypic assay to identify cardioprotective agents Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function Analysis of synaptic vesicle endocytosis in synaptosomes by high-content screening.Meclizine is neuroprotective in models of Huntington's disease.Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants.Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death.Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.Metabolic restructuring during energy-limited states: insights from Artemia franciscana embryos and other animals.Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity.Early deficits in glycolysis are specific to striatal neurons from a rat model of huntington disease.

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P2860

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.

http://www.wikidata.org/entity/Q35101307

description

2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Nutrient-sensitized screening ...... ial respiration to glycolysis.

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Nutrient-sensitized screening ...... ial respiration to glycolysis.

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Nature Biotechnology

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Nutrient-sensitized screening ...... ial respiration to glycolysis.

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Andrew P Wojtovich

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Cenk Ayata

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Clary B Clish

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Fabiana Perocchi

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Paul S Brookes

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Sunil A Sheth

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Vamsi K Mootha

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Vishal M Gohil

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William Chen

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P2860

Current perspectives on the mechanism of action of artemisinins

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

On the Origin of Cancer Cells

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

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249-255

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10.1038/NBT.1606

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1021138603

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20160716

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