Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease
about
Lysosome and calcium dysregulation in Alzheimer's disease: partners in crimeDown-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brainCalpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type miceExpression of calpain-calpastatin system (CCS) member proteins in human lymphocytes of young and elderly individuals; pilot baseline data for the CALPACENT project.Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.The contributions of myelin and axonal caliber to transverse relaxation time in shiverer and neurofilament-deficient mouse models.Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L miceDeclining phosphatases underlie aging-related hyperphosphorylation of neurofilaments.Implicating calpain in tau-mediated toxicity in vivo.The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.Astragalus saponins modulates colon cancer development by regulating calpain-mediated glucose-regulated protein expression.Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture.Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms.Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease.Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects.Calpain dysregulation in Alzheimer's diseaseTruncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE.A neuronal death model: overexpression of neuronal intermediate filament protein peripherin in PC12 cellsDeficient brain insulin signalling pathway in Alzheimer's disease and diabetesβ-Amyloid carrying the Dutch mutation has diverse effects on calpain-mediated toxicity in hippocampal neurons.Caspase-3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons.Activation of protein phosphatase 2B and hyperphosphorylation of Tau in Alzheimer's disease.Proteolytic mechanisms in necrotic cell death and neurodegeneration.Neurofilaments at a glance.Implication of calpain in neuronal apoptosis. A possible regulation of Alzheimer's disease.Involvement of calpain activation in neurodegenerative processes.CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's diseaseInhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain.Semiquantitative proteomic analysis of human hippocampal tissues from Alzheimer's disease and age-matched control brains.Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neuronsCardiac dys-synchronization and arrhythmia in hyperhomocysteinemia.Neurites containing the neurofilament-triplet proteins are selectively vulnerable to cytoskeletal pathology in Alzheimer's disease and transgenic mouse models.Calpain-mediated signaling mechanisms in neuronal injury and neurodegenerationAge-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production.PSEA: Kinase-specific prediction and analysis of human phosphorylation substrates.Axonal degeneration as a therapeutic target in the CNS.Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology.Calpain-14 and its association with eosinophilic esophagitis.
P2860
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P2860
Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Calpain mediates calcium-induc ...... levance to Alzheimer's disease
@ast
Calpain mediates calcium-induc ...... levance to Alzheimer's disease
@en
type
label
Calpain mediates calcium-induc ...... levance to Alzheimer's disease
@ast
Calpain mediates calcium-induc ...... levance to Alzheimer's disease
@en
prefLabel
Calpain mediates calcium-induc ...... levance to Alzheimer's disease
@ast
Calpain mediates calcium-induc ...... levance to Alzheimer's disease
@en
P2093
P2860
P921
P1476
Calpain mediates calcium-induc ...... levance to Alzheimer's disease
@en
P2093
Anna Rudnicki
Anne Cataldo
Barry Boland
Basalingappa L Hungund
Bing Sheng Li
Corrinne Peterhoff
Harish C Pant
Niranjana Amin
Panaiyur Mohan
Ralph A Nixon
P2860
P304
P356
10.1016/S0002-9440(10)63342-1
P407
P577
2004-09-01T00:00:00Z