Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.
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Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiencyNF-κB, the first quarter-century: remarkable progress and outstanding questionsLinear ubiquitination in immunityThe intersection of cell death and inflammasome activationThe linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.Systems-level analysis of innate immunity.SHARPIN is essential for cytokine production, NF-κB signaling, and induction of Th1 differentiation by dendritic cells.TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection.Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling.Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia.ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation.SHARPIN is a key regulator of immune and inflammatory responsesDiscovery of small-molecule inhibitors of the TLR1/TLR2 complexMerck Ad5/HIV induces broad innate immune activation that predicts CD8⁺ T-cell responses but is attenuated by preexisting Ad5 immunity.SHARPIN regulates uropod detachment in migrating lymphocytes.Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.The emerging role of linear ubiquitination in cell signaling.Ubiquitination in signaling to and activation of IKK.Linear ubiquitination-mediated NF-κB regulation and its related disorders.Met1-linked ubiquitination in immune signalling.The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination.The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.The Linear Ubiquitin Assembly Complex Modulates Latent Membrane Protein 1 Activation of NF-κB and Interferon Regulatory Factor 7.Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1.Linear ubiquitin chains: enzymes, mechanisms and biologyAngiogenesis in the skin of SHARPIN-deficient mice with chronic proliferative dermatitis.SHARPIN controls the development of regulatory T cells.Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice."Toll-free" pathways for production of type I interferons
P2860
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P2860
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Systems analysis identifies an ...... e receptor 2 (TLR2) responses.
@ast
Systems analysis identifies an ...... e receptor 2 (TLR2) responses.
@en
type
label
Systems analysis identifies an ...... e receptor 2 (TLR2) responses.
@ast
Systems analysis identifies an ...... e receptor 2 (TLR2) responses.
@en
prefLabel
Systems analysis identifies an ...... e receptor 2 (TLR2) responses.
@ast
Systems analysis identifies an ...... e receptor 2 (TLR2) responses.
@en
P2093
P2860
P356
P1476
Systems analysis identifies an ...... e receptor 2 (TLR2) responses.
@en
P2093
Alan Aderem
Alan H Diercks
Antti Niemistö
Carrie D Johnson
Daniel E Zak
Elizabeth S Gold
Frank Schmitz
Irina Podolsky
Jacques J Peschon
Joe S Valvo
P2860
P304
11536-11541
P356
10.1073/PNAS.1107577108
P407
P577
2011-06-27T00:00:00Z