about
Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain.Activation of P21-activated protein kinase 2 is an independent prognostic predictor for patients with gastric cancerMesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretionProtein kinase CK2 phosphorylates and activates p21-activated kinase 1Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesisCLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent eventsGroup I PAK inhibitor IPA-3 induces cell death and affects cell adhesivity to fibronectin in human hematopoietic cellsAnti-cancer effect of novel PAK1 inhibitor via induction of PUMA-mediated cell death and p21-mediated cell cycle arrest.P21-activated kinase in inflammatory and cardiovascular disease.Essential oil of Pinus koraiensis inhibits cell proliferation and migration via inhibition of p21-activated kinase 1 pathway in HCT116 colorectal cancer cells.Republished: tracing PAKs from GI inflammation to cancerIPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-κB activation.Entamoeba histolytica RacC selectively engages p21-activated kinase effectorsSalmonella modulation of host cell gene expression promotes its intracellular growthPrognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma.P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition.p70 S6-kinase mediates the cooperation between Akt1 and Mek1 pathways in fibroblast-mediated extracellular matrix remodelingDysregulation of PAK1 Is Associated with DNA Damage and Is of Prognostic Importance in Primary Esophageal Small Cell Carcinoma.Characterization of EHop-016, novel small molecule inhibitor of Rac GTPaseA new role for cofilin in retinal neovascularization.Liposome-mediated delivery of the p21 activated kinase-1 (PAK-1) inhibitor IPA-3 limits prostate tumor growth in vivo.Pak1, adjuvant tamoxifen therapy, and breast cancer recurrence risk in a Danish population-based study.TGFβ receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cellsNovel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer.p21-Activated protein kinases and their emerging roles in glucose homeostasis.Tracing PAKs from GI inflammation to cancer.P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells.Rhodiola rosea L. and Alzheimer's Disease: From Farm to Pharmacy.Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer.Investigational serine/threonine kinase inhibitors against prostate cancer metastases.The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes.The p21-activated kinase 1 (Pak1) signalling pathway in cardiac disease: from mechanistic study to therapeutic exploration.PAK1: A Therapeutic Target for Cancer TreatmentPAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis.FOXO1 regulates expression of a microRNA cluster on X chromosome.Methods for treating neurological conditions (WO2011159945).Three-dimensional structural analysis reveals a Cdk5-mediated kinase cascade regulating hepatic biliary network branching in zebrafish.Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
PAK1 as a therapeutic target.
@ast
PAK1 as a therapeutic target.
@en
type
label
PAK1 as a therapeutic target.
@ast
PAK1 as a therapeutic target.
@en
prefLabel
PAK1 as a therapeutic target.
@ast
PAK1 as a therapeutic target.
@en
P2093
P2860
P1476
PAK1 as a therapeutic target.
@en
P2093
Belal Al-Husein
Eugene S Kandel
Julia V Kichina
Payaningal R Somanath
P2860
P304
P356
10.1517/14728222.2010.492779
P407
P577
2010-07-01T00:00:00Z