Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology - Wikidata - wikimedia - TriplyDB

Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology

Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology

http://www.wikidata.org/entity/Q35112497

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Microglial cell dysregulation in brain aging and neurodegeneration The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?Innate immunity in Alzheimer's disease: a complex affair Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism Inflammatory process in Alzheimer's Disease Dynamic self-guiding analysis of Alzheimer's disease.The neuroprotective functions of transforming growth factor beta proteins Suppression of Alzheimer's disease-related phenotypes by geranylgeranylacetone in mice TGF-beta1 blockade of microglial chemotaxis toward Abeta aggregates involves SMAD signaling and down-regulation of CCL5 Metabotropic glutamate receptors: from the workbench to the bedside.Increased expression of the homologue of enhancer-of-split 1 protects neurons from beta amyloid neurotoxicity and hints at an alternative role for transforming growth factor beta1 as a neuroprotector TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke.TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease.Intact memory in TGF-β1 transgenic mice featuring chronic cerebrovascular deficit: recovery with pioglitazone ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis.Meta-Analysis of Transcriptome Data Related to Hippocampus Biopsies and iPSC-Derived Neuronal Cells from Alzheimer's Disease Patients Reveals an Association with FOXA1 and FOXA2 Gene Regulatory Networks.Computational selection and prioritization of candidate genes for fetal alcohol syndrome.Activin A is essential for neurogenesis following neurodegeneration HIV-1 stimulates nuclear entry of amyloid beta via dynamin dependent EEA1 and TGF-β/Smad signaling.Collagen VI protects neurons against Abeta toxicity.Changes of peripheral TGF-β1 depend on monocytes-derived macrophages in Huntington disease Genes contributing to prion pathogenesis Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage A role for age-related changes in TGFbeta signaling in aberrant chondrocyte differentiation and osteoarthritis Transgenic models for cytokine-induced neurological disease.TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons.CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice Neuronal cellular responses to extremely low frequency electromagnetic field exposure: implications regarding oxidative stress and neurodegeneration Dab2 attenuates brain injury in APP/PS1 mice via targeting transforming growth factor-beta/SMAD signaling.Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease Comparative gene expression analysis in mouse models for multiple sclerosis, Alzheimer's disease and stroke for identifying commonly regulated and disease-specific gene changes The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation Alterations in function and expression of ABC transporters at blood-brain barrier under diabetes and the clinical significances.TGF-β1 protection against Aβ1-42-induced neuroinflammation and neurodegeneration in rats.

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Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology

http://www.wikidata.org/entity/Q35112497

description

2006 nî lūn-bûn

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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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name

Deficiency in neuronal TGF-bet ...... tion and Alzheimer's pathology

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Deficiency in neuronal TGF-bet ...... tion and Alzheimer's pathology

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type

label

Deficiency in neuronal TGF-bet ...... tion and Alzheimer's pathology

@ast

Deficiency in neuronal TGF-bet ...... tion and Alzheimer's pathology

@en

prefLabel

Deficiency in neuronal TGF-bet ...... tion and Alzheimer's pathology

@ast

Deficiency in neuronal TGF-bet ...... tion and Alzheimer's pathology

@en

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Journal of Clinical Investigation

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Deficiency in neuronal TGF-bet ...... tion and Alzheimer's pathology

@en

P2093

Amy H Lin

http://www.w3.org/2001/XMLSchema#string

Eliezer Masliah

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Elisabeth Berber

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Frederique Bard

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Ina Tesseur

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Judith Van Can

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Kun Zou

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Lennart Mucke

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Luke Esposito

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Patrick Tremblay

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P2860

Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor

The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

“Mini-mental state”

Alzheimer's disease: genes, proteins, and therapy

Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

Specificity and versatility in tgf-beta signaling through Smads

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.

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3060-3069

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10.1172/JCI27341

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6716787

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17080199

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Alzheimer's disease

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1626127

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