Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.
about
A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic propertiesRNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory MechanismsDevelopment of cell-based assays for in vitro characterization of hepatitis C virus NS3/4A protease inhibitorsMutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine proteaseVX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon CellsSynergy of Small Molecular Inhibitors of Hepatitis C Virus Replication Directed at Multiple Viral TargetsStudying Hepatitis C Virus: Making the Best of a Bad VirusKey steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with DihydroxypyrimidinessiRNAs: potential therapeutic agents against hepatitis C virusLooking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approachSerpin mechanism of hepatitis C virus nonstructural 3 (NS3) protease inhibition: induced fit as a mechanism for narrow specificity.High-throughput screening of low molecular weight NS3-NS4A protease inhibitors using a fluorescence resonance energy transfer substrate.A highly sensitive and selective viral protein detection method based on RNA oligonucleotide nanoparticle.Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug designScreening compounds against HCV based on MAVS/IFN-β pathway in a replicon modelComputational study on the molecular mechanisms of drug resistance of Narlaprevir due to V36M, R155K, V36M+R155K, T54A, and A156T mutations of HCV NS3/4A protease.In-vitro antiviral activity of Solanum nigrum against Hepatitis C Virus.In-vitro model systems to study Hepatitis C Virus.An overview of HCV molecular biology, replication and immune responses.Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B.Label free inhibitor screening of hepatitis C virus (HCV) NS5B viral protein using RNA oligonucleotideRecent developments in target identification against hepatitis C virus.Hepatitis C-HIV coinfection: current and future therapy.Current and emerging therapeutic approaches to hepatitis C infection.A new release on life: emerging concepts in proteolysis and parasite invasion.Achievements and challenges in antiviral drug discovery.Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors.The interferon inducing pathways and the hepatitis C virusResistance mechanisms in HCV: from evolution to intervention.Role of viral and host factors in interferon based therapy of hepatitis C virus infectionViral response to specifically targeted antiviral therapy for hepatitis C and the implications for treatment success.Exploitation of lipid components by viral and host proteins for hepatitis C virus infection.Structural and antigenic definition of hepatitis C virus E2 glycoprotein epitopes targeted by monoclonal antibodies.Inhibition of dengue virus polymerase by blocking of the RNA tunnelZika viral polymerase inhibition using anti-HCV drugs both in market and under clinical trials.2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication.The potential of signal peptide peptidase as a therapeutic target for hepatitis C.Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
P2860
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P2860
Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Approaching a new era for hepa ...... RNA-dependent RNA polymerase.
@ast
Approaching a new era for hepa ...... RNA-dependent RNA polymerase.
@en
type
label
Approaching a new era for hepa ...... RNA-dependent RNA polymerase.
@ast
Approaching a new era for hepa ...... RNA-dependent RNA polymerase.
@en
prefLabel
Approaching a new era for hepa ...... RNA-dependent RNA polymerase.
@ast
Approaching a new era for hepa ...... RNA-dependent RNA polymerase.
@en
P2093
P1433
P1476
Approaching a new era for hepa ...... B RNA-dependent RNA polymerase
@en
P2093
Giovanni Migliaccio
Licia Tomei
Sergio Altamura
Vincenzo Summa
P356
10.1016/S0166-3542(03)00028-7
P577
2003-03-01T00:00:00Z