Nucleoprotein intermediates in HIV-1 DNA integration visualized by atomic force microscopy
about
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.A new class of multimerization selective inhibitors of HIV-1 integraseSolution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.Rous sarcoma virus synaptic complex capable of concerted integration is kinetically trapped by human immunodeficiency virus integrase strand transfer inhibitors.Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasomeA critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.Dialysis purification of integrase-DNA complexes provides high-resolution atomic force microscopy images: dimeric recombinant HIV-1 integrase binding and specific looping on DNA.The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.Retroviral integrase proteins and HIV-1 DNA integrationRetroviral Integrase Structure and DNA Recombination MechanismFeatures, processing states, and heterologous protein interactions in the modulation of the retroviral nucleocapsid protein function.HIV-1 integrase strand transfer inhibitors stabilize an integrase-single blunt-ended DNA complexFRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.DNA requirements for assembly and stability of HIV-1 intasomesThe molecular biology of HIV integrase.Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication.C-Terminal Domain of Integrase Binds between the Two Active SitesA protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase.Structural biology of retroviral DNA integration.The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.Structural and functional insights into foamy viral integraseMultimodal mechanism of action of allosteric HIV-1 integrase inhibitors.HIV-1 integrase multimerization as a therapeutic target.A C-terminal "Tail" Region in the Rous Sarcoma Virus Integrase Provides High Plasticity of Functional Integrase Oligomerization during Intasome Assembly.Retroviral integrase protein and intasome nucleoprotein complex structures.HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis.Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system.
P2860
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P2860
Nucleoprotein intermediates in HIV-1 DNA integration visualized by atomic force microscopy
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Nucleoprotein intermediates in ...... zed by atomic force microscopy
@ast
Nucleoprotein intermediates in ...... zed by atomic force microscopy
@en
type
label
Nucleoprotein intermediates in ...... zed by atomic force microscopy
@ast
Nucleoprotein intermediates in ...... zed by atomic force microscopy
@en
prefLabel
Nucleoprotein intermediates in ...... zed by atomic force microscopy
@ast
Nucleoprotein intermediates in ...... zed by atomic force microscopy
@en
P2093
P2860
P1476
Nucleoprotein intermediates in ...... zed by atomic force microscopy
@en
P2093
Emilios K Dimitriadis
Robert Craigie
Svetlana Kotova
P2860
P304
P356
10.1016/J.JMB.2010.04.026
P407
P577
2010-04-21T00:00:00Z