A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.
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Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulationThe Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular CompoundsStructure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity.Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases.Biochemical and structural analysis of an Eis family aminoglycoside acetyltransferase from bacillus anthracis.The cystathionine-β-synthase domains on the guanosine 5''-monophosphate reductase and inosine 5'-monophosphate dehydrogenase enzymes from Leishmania regulate enzymatic activity in response to guanylate and adenylate nucleotide levels.Inosine 5'-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives.Discovery of a new method for potent drug development using power function of stoichiometry of homomeric biocomplexes or biological nanomotorsBenzoxazoles, phthalazinones, and arylurea-based compounds with IMPDH-independent antibacterial activity against Francisella tularensis.Inhibition of Inosine-5'-monophosphate Dehydrogenase from Bacillus anthracis: Mechanism Revealed by Pre-Steady-State Kinetics.A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases.Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents.
P2860
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P2860
A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
A novel cofactor-binding mode ...... xplains inhibitor selectivity.
@ast
A novel cofactor-binding mode ...... xplains inhibitor selectivity.
@en
type
label
A novel cofactor-binding mode ...... xplains inhibitor selectivity.
@ast
A novel cofactor-binding mode ...... xplains inhibitor selectivity.
@en
prefLabel
A novel cofactor-binding mode ...... xplains inhibitor selectivity.
@ast
A novel cofactor-binding mode ...... xplains inhibitor selectivity.
@en
P2093
P2860
P356
P1476
A novel cofactor-binding mode ...... xplains inhibitor selectivity.
@en
P2093
Andrzej Joachimiak
Deviprasad R Gollapalli
Jerzy Osipiuk
Kavitha Mandapati
Lizbeth Hedstrom
Magdalena Makowska-Grzyska
Minjia Zhang
Natalia Maltseva
Suresh Kumar Gorla
P2860
P304
P356
10.1074/JBC.M114.619767
P407
P577
2015-01-08T00:00:00Z