Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome.
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Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesisDefective control of pre-messenger RNA splicing in human diseaseHow do messenger RNA splicing alterations drive myelodysplasia?Hypoxia is a Key Driver of Alternative Splicing in Human Breast Cancer Cells.The genomic landscape of juvenile myelomonocytic leukemia.Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA.The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.A dynamic intron retention program enriched in RNA processing genes regulates gene expression during terminal erythropoiesis.EBV-miR-BHRF1-2 targets PRDM1/Blimp1: potential role in EBV lymphomagenesis.The Arabidopsis homolog of human minor spliceosomal protein U11-48K plays a crucial role in U12 intron splicing and plant developmentComprehensive mutational analysis of primary and relapse acute promyelocytic leukemia.RNA splicing factors as oncoproteins and tumour suppressors.Lessons from non-canonical splicingVariant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease.Aberrant splicing in maize rough endosperm3 reveals a conserved role for U12 splicing in eukaryotic multicellular development.Chronic lymphocytic leukemia: Time to go past genomics?Evolutionarily conserved exon definition interactions with U11 snRNP mediate alternative splicing regulation on U11-48K and U11/U12-65K genes.Splicing-factor alterations in cancers.Unmasking the U2AF homology motif family: a bona fide protein-protein interaction motif in disguise.Splicing factor gene mutations in hematologic malignancies.Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures.Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.Signaling Pathways Driving Aberrant Splicing in Cancer Cells.Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA.Variant snRNPs: New players within the spliceosome system.Insights from structures of cancer-relevant pre-mRNA splicing factors.Splicing Factor Mutations in Cancer.Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics.IntEREst: intron-exon retention estimator.Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.The prognostic significance of global aberrant alternative splicing in patients with myelodysplastic syndrome
P2860
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P2860
Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome.
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Aberrant splicing of U12-type ...... tant myelodysplastic syndrome.
@ast
Aberrant splicing of U12-type ...... tant myelodysplastic syndrome.
@en
type
label
Aberrant splicing of U12-type ...... tant myelodysplastic syndrome.
@ast
Aberrant splicing of U12-type ...... tant myelodysplastic syndrome.
@en
prefLabel
Aberrant splicing of U12-type ...... tant myelodysplastic syndrome.
@ast
Aberrant splicing of U12-type ...... tant myelodysplastic syndrome.
@en
P2093
P2860
P356
P1476
Aberrant splicing of U12-type ...... tant myelodysplastic syndrome.
@en
P2093
Aiko Sato-Otsubo
Alexander Kohlmann
Arnold Ganser
Deepika Kanojia
Felicitas Thol
H Phillip Koeffler
Henry Yang
Janani Sundaresan
Masashi Sanada
P2860
P2888
P356
10.1038/NCOMMS7042
P407
P577
2015-01-14T00:00:00Z