Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer - Wikidata - wikimedia - TriplyDB

Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer

Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer

http://www.wikidata.org/entity/Q35154300

about

Molecular Subtypes and Personalized Therapy in Metastatic Colorectal Cancer POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers A panoply of errors: polymerase proofreading domain mutations in cancer Endometrial cancer gene panels: clinical diagnostic vs research germline DNA testing.Eukaryotic Mismatch Repair in Relation to DNA Replication Whole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients.Regulation of therapeutic resistance in cancers by receptor tyrosine kinases.Inherited predisposition to colorectal cancer: towards a more complete picture.Advances in Hereditary Colorectal and Pancreatic Cancers.Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.POLE and POLD1 screening in 155 patients with multiple polyps and early-onset colorectal cancer Current and future biomarkers in colorectal cancer.Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and MSH2 somatic mutations.NTHL1 and MUTYH polyposis syndromes: two sides of the same coin?Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae.Detection of Germline Mutations in Patients with Epithelial Ovarian Cancer Using Multi-Gene Panels: Beyond BRCA1/2.Risk of colorectal cancer for carriers of a germ-line mutation in POLE or POLD1.

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P2860

Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer

http://www.wikidata.org/entity/Q35154300

description

2014 nî lūn-bûn

@nan

2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Germline variants in POLE are ...... ir deficient colorectal cancer

@ast

Germline variants in POLE are ...... ir deficient colorectal cancer

@en

type

label

Germline variants in POLE are ...... ir deficient colorectal cancer

@ast

Germline variants in POLE are ...... ir deficient colorectal cancer

@en

prefLabel

Germline variants in POLE are ...... ir deficient colorectal cancer

@ast

Germline variants in POLE are ...... ir deficient colorectal cancer

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European Journal of Human Genetics

P1476

Germline variants in POLE are ...... ir deficient colorectal cancer

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Brendy van den Akker

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C Marleen Kets

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Carli M Tops

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Dina Ruano

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Fadwa A Elsayed

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Hans Morreau

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Juul T Wijnen

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Marjolijn J Ligtenberg

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Melanie Schrumpf

http://www.w3.org/2001/XMLSchema#string

P2860

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Comprehensive molecular characterization of human colon and rectal cancer

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity.

The 3' to 5' exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication

Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis

DNA replication fidelity and cancer

New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis

Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR.

Biallelic MUTYH mutations can mimic Lynch syndrome

P2888

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1080-1084

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10.1038/EJHG.2014.242

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23

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Arjen R Mensenkamp

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colorectal cancer

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