Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α
about
FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascadePhosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damageInsulin receptor signaling in normal and insulin-resistant statesBiophysical methods for the characterization of PTEN/lipid bilayer interactionsPKCβ phosphorylates PI3Kγ to activate it and release it from GPCR controlUsing hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinasesStructural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitorsThe function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding sitePI3K-independent AKT activation in cancers: a treasure trove for novel therapeuticsSignaling by the phosphoinositide 3-kinase family in immune cellsDynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3KCharacterization of a tumor-associated activating mutation of the p110β PI 3-kinase.CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex.Oncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α.The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes.Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling PathwayAnnotating cancer variants and anti-cancer therapeutics in reactome.Phosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases.Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis.Novel approaches to inhibitor design for the p110β phosphoinositide 3-kinase.Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects.Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities.Novel PIK3CD mutations affecting N-terminal residues of p110δ cause activated PI3Kδ syndrome (APDS) in humans.Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas.miRNA profiling during antigen-dependent T cell activation: A role for miR-132-3p.Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1.PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingAn overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery.Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.PI3K gain of function mutants phosphorylate PIP2 to PIP3PI3K-containing complexes phosphorylate PIP2 to PIP3Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases.PI3K phosphorylates PIP2 to PIP3_R-HSA-1257604
P2860
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P2860
Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Dynamics of the phosphoinositi ...... regulation distinct from p110α
@ast
Dynamics of the phosphoinositi ...... regulation distinct from p110α
@en
type
label
Dynamics of the phosphoinositi ...... regulation distinct from p110α
@ast
Dynamics of the phosphoinositi ...... regulation distinct from p110α
@en
prefLabel
Dynamics of the phosphoinositi ...... regulation distinct from p110α
@ast
Dynamics of the phosphoinositi ...... regulation distinct from p110α
@en
P2093
P2860
P50
P1433
P1476
Dynamics of the phosphoinositi ...... regulation distinct from p110α
@en
P2093
Alex Berndt
Oscar Vadas
Tara Finegan
P2860
P304
P356
10.1016/J.STR.2011.06.003
P577
2011-08-01T00:00:00Z