Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist - Wikidata - wikimedia - TriplyDB

Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist

Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist

http://www.wikidata.org/entity/Q35161744

about

Endothelin Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension Regulation of the Apelinergic System and Its Potential in Cardiovascular Disease: Peptides and Small Molecules as Tools for Discovery.Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders.Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature.The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and Pathology [Pyr1]Apelin-13(1-12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr1]Apelin-13.Apelin administration improves insulin sensitivity in overweight men during hyperinsulinaemic-euglycaemic clamp.Agonist-induced internalization and desensitization of the apelin receptor.Expanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models.Cardiac action of the first G protein biased small molecule apelin agonist.Pharmacological targeting of apelin impairs glioblastoma growth.The apelinergic system as an alternative to catecholamines in low-output septic shock.Development of Potent and Metabolically Stable APJ Ligands with High Therapeutic Potential.Structure-activity relationship of novel macrocyclic biased apelin receptor agonists.Apelinergic System Structure and Function.Activation of Large Conductance, Calcium-Activated K Channels by Nitric Oxide Mediates Apelin-Induced Relaxation of Coronary Arteries.Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension.

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Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist

http://www.wikidata.org/entity/Q35161744

description

2015 nî lūn-bûn

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2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի փետրվարին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Design, characterization, and ...... biased apelin receptor agonist

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Design, characterization, and ...... biased apelin receptor agonist

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Design, characterization, and ...... biased apelin receptor agonist

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Design, characterization, and ...... biased apelin receptor agonist

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Design, characterization, and ...... biased apelin receptor agonist

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Design, characterization, and ...... biased apelin receptor agonist

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HYPERTENSIONAHA.114.05099

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Design, characterization, and ...... biased apelin receptor agonist

@en

P2093

Aimee L Brame

http://www.w3.org/2001/XMLSchema#string

Ian B Wilkinson

http://www.w3.org/2001/XMLSchema#string

Robert C Glen

http://www.w3.org/2001/XMLSchema#string

Rubben Torella

http://www.w3.org/2001/XMLSchema#string

P2860

Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor

The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo

Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ

Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility

Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms

Apelin has in vivo inotropic effects on normal and failing hearts

Structural insight into G-protein coupled receptor binding by apelin

Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain.

Modulation of the apelin/APJ system in heart failure and atherosclerosis in man

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension

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834-840

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scholarly article

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10.1161/HYPERTENSIONAHA.114.05099

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4

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65

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Joseph Cheriyan

Anthony P Davenport

Janet J. Maguire

P577

2015-02-23T00:00:00Z

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272840894

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25712721

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4354462

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