G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin.
about
The impact of GPCR structures on pharmacology and structure-based drug designFunction, structure and therapeutic potential of complement C5a receptorsA systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological dataAllosteric modulation of metabotropic glutamate receptors.GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors.Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach.A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanizationSemi-supervised drug-protein interaction prediction from heterogeneous biological spaces.Structural basis for μ-opioid receptor binding and activation.The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors.The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes.Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes.Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosaProbing a model of a GPCR/ligand complex in an explicit membrane environment: the human cholecystokinin-1 receptor.The G protein-coupled receptor rhodopsin in the native membraneG protein-coupled receptor rhodopsin: a prospectus.Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin.Molecular docking of 2-(benzimidazol-2-ylthio)-N-phenylacetamide-derived small-molecule agonists of human formyl peptide receptor 1A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.Exploring human adenosine A3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety.Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders.One-step generation of mice carrying a conditional allele together with an HA-tag insertion for the delta opioid receptor.Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.Comparative docking study of anibamine as the first natural product CCR5 antagonist in CCR5 homology models.Evolutionary analysis of rhodopsin and cone pigments: connecting the three-dimensional structure with spectral tuning and signal transferInfluence of proline on the thermostability of the active site and membrane arrangement of transmembrane proteins.Hybrid approach to structure modeling of the histamine H3 receptor: Multi-level assessment as a tool for model verificationProtein-ligand interaction prediction: an improved chemogenomics approach.
P2860
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P2860
G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin.
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
G protein-coupled receptor dru ...... rystal structure of rhodopsin.
@ast
G protein-coupled receptor dru ...... rystal structure of rhodopsin.
@en
type
label
G protein-coupled receptor dru ...... rystal structure of rhodopsin.
@ast
G protein-coupled receptor dru ...... rystal structure of rhodopsin.
@en
prefLabel
G protein-coupled receptor dru ...... rystal structure of rhodopsin.
@ast
G protein-coupled receptor dru ...... rystal structure of rhodopsin.
@en
P2860
P1476
G protein-coupled receptor dru ...... crystal structure of rhodopsin
@en
P2093
J Ballesteros
K Palczewski
P2860
P304
P577
2001-09-01T00:00:00Z