Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. - Wikidata - wikimedia - TriplyDB

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells.

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells.

http://www.wikidata.org/entity/Q35164701

about

Tumor-derived exosomes in cancer progression and treatment failure Heparin in malignant glioma: review of preclinical studies and clinical results Harnessing the genome for characterization of G-protein coupled receptors in cancer pathogenesis Rho GTPases and their roles in cancer metabolism Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition Hypoxic enhancement of exosome release by breast cancer cells.Plasma membrane-derived microvesicles released from tip endothelial cells during vascular sprouting Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non-aggressive neighbouring cells.Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles.Regulated delivery of molecular cargo to invasive tumour-derived microvesicles Activation of protease-activated receptor 2 induces VEGF independently of HIF-1.Potential Coagulation Factor-Driven Pro-Inflammatory Responses in Ovarian Cancer Tissues Associated with Insufficient O₂ and Plasma Supply.Exosomal Proteome Profiling: A Potential Multi-Marker Cellular Phenotyping Tool to Characterize Hypoxia-Induced Radiation Resistance in Breast Cancer.A new mosaic pattern in glioma vascularization: exogenous endothelial progenitor cells integrating into the vessels containing tumor-derived endothelial cells.Extracellular Vesicles As Modulators of Tumor Microenvironment and Disease Progression in Glioma Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.Microparticles mediated cross-talk between tumoral and endothelial cells promote the constitution of a pro-metastatic vascular niche through Arf6 up regulation.Microvesicles derived from human umbilical cord mesenchymal stem cells stimulated by hypoxia promote angiogenesis both in vitro and in vivo.Glioblastoma extracellular vesicles: reservoirs of potential biomarkers.Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger.Extracellular membrane vesicles and immune regulation in the brain.Extracellular vesicles and their synthetic analogues in aging and age-associated brain diseases.Oncogenic extracellular vesicles in brain tumor progression The tick-derived inhibitor Ixolaris prevents tissue factor signaling on tumor cells.Putative Links Between Sleep Apnea and Cancer: From Hypotheses to Evolving Evidence.Sorting it out: regulation of exosome loading Protease-activated receptors (PARs)--biology and role in cancer invasion and metastasis.The hypoxic tumor microenvironment: A driving force for breast cancer progression.CSE1L, a novel microvesicle membrane protein, mediates Ras-triggered microvesicle generation and metastasis of tumor cells.Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study.Molecular pathways: tumor-derived microvesicles and their interactions with immune cells in vivo Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid Raft-mediated endocytosis negatively regulated by caveolin-1.Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model.Transfer of extracellular vesicles during immune cell-cell interactions.Emerging roles of extracellular vesicles in the adaptive response of tumour cells to microenvironmental stress.Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity.The critical role of the tumor microenvironment in shaping natural killer cell-mediated anti-tumor immunity.The reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux Teleocidin A2 inhibits human proteinase-activated receptor 2 signaling in tumor cells.

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P2860

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells.

http://www.wikidata.org/entity/Q35164701

description

2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Hypoxia triggers a proangiogen ...... ignaling in endothelial cells.

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Hypoxia triggers a proangiogen ...... ignaling in endothelial cells.

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Hypoxia triggers a proangiogen ...... ignaling in endothelial cells.

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Hypoxia triggers a proangiogen ...... ignaling in endothelial cells.

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Hypoxia triggers a proangiogen ...... ignaling in endothelial cells.

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Hypoxia triggers a proangiogen ...... ignaling in endothelial cells.

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Hypoxia triggers a proangiogen ...... signaling in endothelial cells

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Helena C Christianson

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Maria C Johansson

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Matthias Mörgelin

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Paulina Kucharzewska

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Stefan Sköld

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Tobias Löfstedt

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Wolfram Ruf

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P2860

HB-EGF is a potent inducer of tumor growth and angiogenesis

A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Nanotubes, exosomes, and nucleic acid-binding peptides provide novel mechanisms of intercellular communication in eukaryotic cells: implications in health and disease

Signaling of the tissue factor coagulation pathway in angiogenesis and cancer

Exploiting tumour hypoxia in cancer treatment

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

Shedding microvesicles: artefacts no more

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13147-13152

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10.1073/PNAS.1104261108

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