Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation. - Wikidata - wikimedia - TriplyDB

Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation.

Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation.

http://www.wikidata.org/entity/Q35170755

about

The current state of eukaryotic DNA base damage and repair Transcription Blockage Leads to New Beginnings Nucleases in homologous recombination as targets for cancer therapy Nucleotide excision repair in eukaryotes Exonuclease 1-dependent and independent mismatch repair NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.Damaged DNA-binding protein down-regulates epigenetic mark H3K56Ac through histone deacetylase 1 and 2.Excision of translesion synthesis errors orchestrates responses to helix-distorting DNA lesions.Exonuclease 1 (EXO1) gene variation and melanoma risk Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster Sumoylation regulates EXO1 stability and processing of DNA damage.Bringing It All Together: Coupling Excision Repair to the DNA Damage Checkpoint.DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH).ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress.Chemotherapy induced DNA damage response: convergence of drugs and pathways Smad4 loss in mouse keratinocytes leads to increased susceptibility to UV carcinogenesis with reduced Ercc1-mediated DNA repair Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.Epigenetic regulation of genomic integrity.DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress.XPF knockout via CRISPR/Cas9 reveals that ERCC1 is retained in the cytoplasm without its heterodimer partner XPF.ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle.Impact of Age and Insulin-Like Growth Factor-1 on DNA Damage Responses in UV-Irradiated Human Skin.PostExcision Events in Human Nucleotide Excision Repair.Nucleotide excision repair-dependent DNA double-strand break formation and ATM signaling activation in mammalian quiescent cells.FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.Molecular effects of 1-naphthyl-methylcarbamate and solar radiation exposures on human melanocytes.Emerging roles for histone modifications in DNA excision repair.Generation of DNA single-strand displacement by compromised nucleotide excision repair.Processing closely spaced lesions during Nucleotide Excision Repair triggers mutagenesis in E. coli.Study of UV-induced DNA Repair Factor Recruitment: Kinetics and Dynamics.Insulin-like Growth Factor 1 Receptor Signaling Is Required for Optimal ATR-CHK1 Kinase Signaling in Ultraviolet B (UVB)-irradiated Human Keratinocytes.Roles of UVA radiation and DNA damage responses in melanoma pathogenesis.

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Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation.

http://www.wikidata.org/entity/Q35170755

description

2011 nî lūn-bûn

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2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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Human exonuclease 1 connects n ...... in response to UV irradiation.

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P2093

Alan R Lehmann

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Federica Marini

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Marco Muzi-Falconi

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Paolo Plevani

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Ross Cloney

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Sara Pizzi

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Sarah Sertic

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P2860

The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA

Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells

DNA nucleotide excision repair-dependent signaling to checkpoint activation

Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

Transcription-coupled repair and premature ageing

The DNA damage response: ten years after

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