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A comparative study of Lrrk2 function in primary neuronal cultures.

A comparative study of Lrrk2 function in primary neuronal cultures.

http://www.wikidata.org/entity/Q35176338

about

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease The Progress of Induced Pluripotent Stem Cells as Models of Parkinson's Disease Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration Role of LRRK2 kinase dysfunction in Parkinson disease Leucine-rich repeat kinase 2 for beginners: six key questions.Short- and long-term effects of LRRK2 on axon and dendrite growth VPS35 mutations in Parkinson disease Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications LRRK2 Parkinson disease mutations enhance its microtubule association.Mitochondrial dysfunction in genetic animal models of Parkinson's disease Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity.The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities Cellular effects of LRRK2 mutations.14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.The role of intracellular trafficking and the VPS10d receptors in Alzheimer's disease.LRRK2: an éminence grise of Wnt-mediated neurogenesis?Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.Development of inducible leucine-rich repeat kinase 2 (LRRK2) cell lines for therapeutics development in Parkinson's disease.On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies.Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models.Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation.Genetics and genomics of Parkinson's disease.LRRK2 Pathways Leading to Neurodegeneration.Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2.Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson's disease.

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P2860

A comparative study of Lrrk2 function in primary neuronal cultures.

http://www.wikidata.org/entity/Q35176338

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

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name

A comparative study of Lrrk2 function in primary neuronal cultures.

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A comparative study of Lrrk2 function in primary neuronal cultures.

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type

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A comparative study of Lrrk2 function in primary neuronal cultures.

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A comparative study of Lrrk2 function in primary neuronal cultures.

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prefLabel

A comparative study of Lrrk2 function in primary neuronal cultures.

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A comparative study of Lrrk2 function in primary neuronal cultures.

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J.PARKRELDIS.2010.08.018

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Parkinsonism and Related Disorders

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A comparative study of Lrrk2 function in primary neuronal cultures.

@en

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Bahareh Behrouz

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Heather L Melrose

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Joel E Beevers

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Justus C Dächsel

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Matthew J Farrer

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Mei Yue

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P2860

Kinase activity of mutant LRRK2 mediates neuronal toxicity

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

Alsin/Rac1 signaling controls survival and growth of spinal motoneurons

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

Dynamic and redundant regulation of LRRK2 and LRRK1 expression.

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650-655

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10.1016/J.PARKRELDIS.2010.08.018

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20850369

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3159957

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