Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.
about
Strategies to achieve conditional gene mutation in micePreclinical mouse cancer models: a maze of opportunities and challenges.Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers.Utilizing past and present mouse systems to engineer more relevant pancreatic cancer modelsAn extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancerAtm deletion with dual recombinase technology preferentially radiosensitizes tumor endotheliumInitiation of metastatic breast carcinoma by targeting of the ductal epithelium with adenovirus-cre: a novel transgenic mouse model of breast cancer.Autophagy is required for glucose homeostasis and lung tumor maintenance.Prognostic impact of Jab1, p16, p21, p62, Ki67 and Skp2 in soft tissue sarcomas.A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapyNCI's provocative questions on cancer: some answers to ignite discussion.Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcomaMinireview: animal models and mechanisms of ovarian cancer development.TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis.Generation of primary tumors with Flp recombinase in FRT-flanked p53 miceThe generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis.Tissue-specific tumorigenesis: context matters.PIK3CA(H1047R) Accelerates and Enhances KRAS(G12D)-Driven Lung Tumorigenesis.The Challenge of Cancer Genomics in Rare Nervous System Neoplasms: Malignant Peripheral Nerve Sheath Tumors as a Paradigm for Cross-Species Comparative Oncogenomics.Sequential inductions of the ZEB1 transcription factor caused by mutation of Rb and then Ras proteins are required for tumor initiation and progression.Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma.The a"MAZE"ing world of lung-specific transgenic mice.Overview of KRAS-Driven Genetically Engineered Mouse Models of Non-Small Cell Lung Cancer.Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets.p21 overexpression sensitizes osteosarcoma U2OS cells to cisplatin via evoking caspase-3 and Bax/Bcl-2 cascade.Effective utilization and appropriate selection of genetically engineered mouse models for translational integration of mouse and human trials.Differing tumor-suppressor functions of Arf and p53 in murine basal cell carcinoma initiation and progression.Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft tissue sarcoma growth depend on tumor developmental stage.Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma.Deconstructing networks of p53-mediated tumor suppression in vivo.Different thresholds of ZEB1 are required for Ras-mediated tumour initiation and metastasis.Rb1 family mutation is sufficient for sarcoma initiation.Autochthonous murine models for the study of smoker and never-smoker associated lung cancers
P2860
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P2860
Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.
@ast
Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.
@en
type
label
Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.
@ast
Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.
@en
prefLabel
Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.
@ast
Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.
@en
P2093
P2860
P1433
P1476
Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.
@en
P2093
Denise Crowley
Nathan P Young
Tyler Jacks
P2860
P304
P356
10.1158/0008-5472.CAN-10-4563
P407
P577
2011-04-21T00:00:00Z