Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action. - Wikidata - wikimedia - TriplyDB

Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action.

Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action.

http://www.wikidata.org/entity/Q35185934

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In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors Fragment screening and HIV therapeutics Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate HIV-1 polymerase inhibition by nucleoside analogs: cellular- and kinetic parameters of efficacy, susceptibility and resistance selection Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity Identification of low-molecular weight inhibitors of HIV-1 reverse transcriptase using a cell-based high-throughput screening system.Effects of the W153L substitution in HIV reverse transcriptase on viral replication and drug resistance to multiple categories of reverse transcriptase inhibitors.Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.Identification and characterization of a novel HIV-1 nucleotide-competing reverse transcriptase inhibitor series.HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase.Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.Subtype-specific analysis of the K65R substitution in HIV-1 that confers hypersusceptibility to a novel nucleotide-competing reverse transcriptase inhibitor.Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening.Mutagenesis of human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of ribonuclease H activity.SJP-L-5, a novel small-molecule compound, inhibits HIV-1 infection by blocking viral DNA nuclear entry.Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses Human immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise.Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection.Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer.Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors".Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates."Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.Impact of primer-induced conformational dynamics of HIV-1 reverse transcriptase on polymerase translocation and inhibition.TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses.Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions.The impact of individual human immunodeficiency virus type 1 protease mutations on drug susceptibility is highly influenced by complex interactions with the background protease sequence.Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase.Computational development of rubromycin-based lead compounds for HIV-1 reverse transcriptase inhibition.

P2860

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P2860

Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action.

http://www.wikidata.org/entity/Q35185934

description

2006 nî lūn-bûn

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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年论文

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Indolopyridones inhibit human ...... h a novel mechanism of action.

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Indolopyridones inhibit human ...... h a novel mechanism of action.

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Indolopyridones inhibit human ...... h a novel mechanism of action.

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Indolopyridones inhibit human ...... h a novel mechanism of action.

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P2093

Bart Kesteleyn

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Bertrand Van Schoubroeck

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Dirk Jochmans

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Eva Bettens

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Herwig Van Marck

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Inky De Baere

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Jérôme Deval

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Kurt Hertogs

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Marcia Van Ginderen

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Maryam Ehteshami

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P2860

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

Multidrug-resistant human immunodeficiency virus type 1 strains resulting from combination antiretroviral therapy

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine

Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-di

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

P304

12283-12292

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10.1128/JVI.00889-06

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24

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1676280

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