HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.
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Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with DihydroxypyrimidinesStructure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active SitePhosphonoformic Acid Inhibits Viral Replication by Trapping the Closed Form of the DNA PolymeraseComplexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradationStructural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse TranscriptaseStructures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavageNovel approaches to inhibiting HIV-1 replication.Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation.Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studiesThe biology and synthesis of α-hydroxytropolones.Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.Role of HIV-1 nucleocapsid protein in HIV-1 reverse transcription.Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase.Inhibition of the ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones.Mutagenesis of human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of ribonuclease H activity.Synthetic α-Hydroxytropolones as Inhibitors of HIV Reverse Transcriptase Ribonuclease H Activity.Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism.Human immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise.Synthetic α-Hydroxytropolones Inhibit Replication of Wild-Type and Acyclovir-Resistant Herpes Simplex Viruses.Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase InhibitorsDesign, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H.Preferred sequences within a defined cleavage window specify DNA 3' end-directed cleavages by retroviral RNases HExploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase.Treatment options beyond IFNα and NUCs for chronic HBV infection: expectations for tomorrow.HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently.Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase.Identification of spirocyclic or phosphate substituted quinolizine derivatives as novel HIV-1 integrase inhibitors: a patent evaluation of WO2016094197A1, WO2016094198A1 and WO2016154527A1.Arm-specific cleavage and mutation during reverse transcription of 2΄,5΄-branched RNA by Moloney murine leukemia virus reverse transcriptaseConformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.Positional adaptability in the design of mutation-resistant nonnucleoside HIV-1 reverse transcriptase inhibitors: a supramolecular perspective.Inhibition of the DNA polymerase and RNase H activities of HIV-1 reverse transcriptase and HIV-1 replication by Brasenia schreberi (Junsai) and Petasites japonicus (Fuki) components.Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase.Transient kinetic analyses of the ribonuclease H cleavage activity of HIV-1 reverse transcriptase in complex with efavirenz and/or a β-thujaplicinol analogue.Developing and evaluating inhibitors against the RNase H active site of HIV-1 RT.High-Technology Therapy Using Biomolecules or Synthetic Compounds for HIV InhibitionHIV Reverse Transcriptase Inhibitors
P2860
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P2860
HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
HIV-1 reverse transcriptase ca ...... ations for RNase H inhibition.
@ast
HIV-1 reverse transcriptase ca ...... ations for RNase H inhibition.
@en
HIV-1 reverse transcriptase ca ...... ations for RNase H inhibition.
@nl
type
label
HIV-1 reverse transcriptase ca ...... ations for RNase H inhibition.
@ast
HIV-1 reverse transcriptase ca ...... ations for RNase H inhibition.
@en
HIV-1 reverse transcriptase ca ...... ations for RNase H inhibition.
@nl
prefLabel
HIV-1 reverse transcriptase ca ...... ations for RNase H inhibition.
@ast
HIV-1 reverse transcriptase ca ...... ations for RNase H inhibition.
@en
HIV-1 reverse transcriptase ca ...... ations for RNase H inhibition.
@nl
P2093
P2860
P1476
HIV-1 reverse transcriptase ca ...... ations for RNase H inhibition.
@en
P2093
Greg L Beilhartz
Jason Rausch
Matthias Götte
Michaela Wendeler
Noel Baichoo
Stuart Le Grice
P2860
P304
P356
10.1016/J.JMB.2009.03.025
P407
P577
2009-03-13T00:00:00Z