Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders.
about
Nuclear Tau and Its Potential Role in Alzheimer's DiseaseGerminal and Somatic Trisomy 21 Mosaicism: How Common is it, What are the Implications for Individual Carriers and How Does it Come About?Amyloid precursor protein (APP) regulates synaptic structure and functionAlzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function.Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP.Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3.Mechanisms and consequences of aneuploidy and chromosome instability in the aging brainGlutamate as a hippocampal neuron survival factor: an inherited defect in the trisomy 16 mouse.Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age.Mitotic spindle defects and chromosome mis-segregation induced by LDL/cholesterol-implications for Niemann-Pick C1, Alzheimer's disease, and atherosclerosis.Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains.Chromosomal Copy Number Variation in Saccharomyces pastorianus Is Evidence for Extensive Genome Dynamics in Industrial Lager Brewing Strains.Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors.A fresh perspective from immunologists and vaccine researchers: active vaccination strategies to prevent and reverse Alzheimer's disease.A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau.The genomically mosaic brain: aneuploidy and more in neural diversity and disease.Distribution of interspersed repeats (Alu and Kpn) on NotI restriction fragments of human chromosome 21Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy.Sensitive pupil response of early-onset alzheimer's patients to a dilute mixture of cholinergic antagonist and α-Adrenergic stimulant.GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny.X chromosome aneuploidy in the Alzheimer's disease brain.Role of Trisomy 21 Mosaicism in Sporadic and Familial Alzheimer's Disease.Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death.Combined association of Presenilin-1 and Apolipoprotein E polymorphisms with maternal meiosis II error in Down syndrome births.Alzheimer disease: the new agenda.Maternal age, somatic mosaicism, and Alzheimer disease.Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer's Disease.Mitotic Defects Lead to Neuronal Aneuploidy and Apoptosis in Frontotemporal Lobar Degeneration Caused by MAPT Mutations.The DNA replication stress hypothesis of Alzheimer's disease.Genome instability in Alzheimer disease.
P2860
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P2860
Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders.
description
1991 nî lūn-bûn
@nan
1991 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Review and hypothesis: Alzheim ...... n may underlie both disorders.
@ast
Review and hypothesis: Alzheim ...... n may underlie both disorders.
@en
type
label
Review and hypothesis: Alzheim ...... n may underlie both disorders.
@ast
Review and hypothesis: Alzheim ...... n may underlie both disorders.
@en
prefLabel
Review and hypothesis: Alzheim ...... n may underlie both disorders.
@ast
Review and hypothesis: Alzheim ...... n may underlie both disorders.
@en
P2860
P1476
Review and hypothesis: Alzheim ...... n may underlie both disorders.
@en
P2093
P2860
P304
P407
P577
1991-06-01T00:00:00Z