Transcription and translation of deleted mitochondrial genomes in Kearns-Sayre syndrome: implications for pathogenesis
about
Replication-competent human mitochondrial DNA lacking the heavy-strand promoter regionAbsolute quantitation of a heteroplasmic mitochondrial DNA deletion using a multiplex three-primer real-time PCR assay.Juvenile Kearns-Sayre syndrome initially misdiagnosed as a psychosomatic disorderUltra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins.Two novel pathogenic mitochondrial DNA mutations affecting organelle number and protein synthesis. Is the tRNA(Leu(UUR)) gene an etiologic hot spot?Pearson's marrow-pancreas syndrome. A multisystem mitochondrial disorder in infancy.DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.A novel mitochondrial DNA deletion in a patient with Kearns-Sayre syndrome: a late-onset of the fatal cardiac conduction deficit and cardiomyopathy accompanying long-term rGH treatmentRearrangements of human mitochondrial DNA (mtDNA): new insights into the regulation of mtDNA copy number and gene expressionMitochondrial nucleoids maintain genetic autonomy but allow for functional complementation.Detection of a specific mitochondrial DNA deletion in tissues of older humans.Mitochondrial DNA Rearrangement Spectrum in Brain Tissue of Alzheimer's Disease: Analysis of 13 CasesSimultaneous quantification of mitochondrial DNA copy number and deletion ratio: a multiplex real-time PCR assay.Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.Human mitochondrial DNA: roles of inherited and somatic mutations.Mitochondrial DNA in sickness and in health.Mitochondrial genome expression in a mutant strain of D. subobscura, an animal model for large scale mtDNA deletion.Biochemical analysis of respiratory function in cybrid cell lines harbouring mitochondrial DNA mutations.Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript.Pathological mechanisms underlying single large-scale mitochondrial DNA deletions.
P2860
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P2860
Transcription and translation of deleted mitochondrial genomes in Kearns-Sayre syndrome: implications for pathogenesis
description
1990 nî lūn-bûn
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1990 թուականի Մարտին հրատարակուած գիտական յօդուած
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1990 թվականի մարտին հրատարակված գիտական հոդված
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1990年の論文
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1990年論文
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1990年論文
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1990年論文
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1990年論文
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1990年論文
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1990年论文
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Transcription and translation ...... implications for pathogenesis
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Transcription and translation ...... implications for pathogenesis
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Transcription and translation ...... implications for pathogenesis
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Transcription and translation ...... implications for pathogenesis
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Transcription and translation ...... implications for pathogenesis
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Transcription and translation ...... implications for pathogenesis
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Transcription and translation ...... implications for pathogenesis
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1990-03-01T00:00:00Z