Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin. - Wikidata - wikimedia - TriplyDB

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin.

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin.

http://www.wikidata.org/entity/Q35202721

about

Mutual relationships between transcription and pre-mRNA processing in the synthesis of mRNA Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure Getting up to speed with transcription elongation by RNA polymerase II Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4 AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter NUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1 replication by increasing Tat-mediated viral transcription on the HIV-1 LTR promoter Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb Human ALKBH4 interacts with proteins associated with transcription Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.Mechanisms of HIV Transcriptional Regulation by Drugs of Abuse.Mechanism and factors that control HIV-1 transcription and latency activation LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.Control of transcriptional elongation.RNA polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation: A tail of two kinases.BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia.AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications.Identification of hidden relationships from the coupling of hydrophobic cluster analysis and domain architecture information.RNA polymerase II transcription elongation control.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription.The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition.PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription.The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output.MD simulation of the Tat/Cyclin T1/CDK9 complex revealing the hidden catalytic cavity within the CDK9 molecule upon Tat binding.A mutant Tat protein inhibits infection of human cells by strains from diverse HIV-1 subtypes MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours.HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency.Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain The effects of cocaine on HIV transcription HIV-1 transcription and latency: an update.The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II.

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Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin.

http://www.wikidata.org/entity/Q35202721

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年学术文章

@wuu

2011年学术文章

@zh-cn

2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

name

Human Polymerase-Associated Fa ...... NA polymerase II on chromatin.

@ast

Human Polymerase-Associated Fa ...... NA polymerase II on chromatin.

@en

type

label

Human Polymerase-Associated Fa ...... NA polymerase II on chromatin.

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Human Polymerase-Associated Fa ...... NA polymerase II on chromatin.

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prefLabel

Human Polymerase-Associated Fa ...... NA polymerase II on chromatin.

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Human Polymerase-Associated Fa ...... NA polymerase II on chromatin.

@en

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PNAS.1107107108

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Proceedings of the National Academy of Sciences of the United States of America

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Human Polymerase-Associated Fa ...... NA polymerase II on chromatin.

@en

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Bijan Sobhian

http://www.w3.org/2001/XMLSchema#string

Caleb K Chan

http://www.w3.org/2001/XMLSchema#string

Min Liu

http://www.w3.org/2001/XMLSchema#string

Monsef Benkirane

http://www.w3.org/2001/XMLSchema#string

Nanhai He

http://www.w3.org/2001/XMLSchema#string

Qiang Zhou

http://www.w3.org/2001/XMLSchema#string

Seemay Chou

http://www.w3.org/2001/XMLSchema#string

Tom Alber

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Yuhua Xue

http://www.w3.org/2001/XMLSchema#string

P2860

Transcriptional activators enhance polyadenylation of mRNA precursors

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

Core transcriptional regulatory circuitry in human embryonic stem cells

c-Myc regulates transcriptional pause release

High-resolution profiling of histone methylations in the human genome

Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription.

hDOT1L links histone methylation to leukemogenesis.

ELL2, a new member of an ELL family of RNA polymerase II elongation factors

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10.1073/PNAS.1107107108

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