HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold
about
P-TEFb goes viralTranscriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cureThe AFF4 scaffold binds human P-TEFb adjacent to HIV TatCrystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoterNegative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat.Identification of HIV-1 Tat-Associated Proteins Contributing to HIV-1 Transcription and Latency.Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults.Mechanisms of HIV Transcriptional Regulation by Drugs of Abuse.Mechanism and factors that control HIV-1 transcription and latency activationUnperturbed posttranscriptional regulatory Rev protein function and HIV-1 replication in astrocytesCharacterization of the influence of mediator complex in HIV-1 transcription.A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation.Viral-host interactions that control HIV-1 transcriptional elongationGene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription.A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency.Inhibition of HIV-1 transcription and replication by a newly identified cyclin T1 splice variant.The effects of cocaine on HIV transcriptionInsights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.Regulation of CDK9 activity by phosphorylation and dephosphorylation.Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcriptionRole of Host Factors on the Regulation of Tat-Mediated HIV-1 Transcription.P-TEFb goes viral.Quantification of the HIV transcriptional activator complex in live cells by image-based protein-protein interaction analysis.AF4 and AF4N protein complexes: recruitment of P-TEFb kinase, their interactome and potential functionsBuilding a super elongation complex for HIV.Schizosaccharomyces pombe Pol II transcription elongation factor ELL functions as part of a rudimentary super elongation complex
P2860
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P2860
HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold
description
2012 nî lūn-bûn
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name
HIV-1 Tat recruits transcripti ...... along a flexible AFF4 scaffold
@ast
HIV-1 Tat recruits transcripti ...... along a flexible AFF4 scaffold
@en
type
label
HIV-1 Tat recruits transcripti ...... along a flexible AFF4 scaffold
@ast
HIV-1 Tat recruits transcripti ...... along a flexible AFF4 scaffold
@en
prefLabel
HIV-1 Tat recruits transcripti ...... along a flexible AFF4 scaffold
@ast
HIV-1 Tat recruits transcripti ...... along a flexible AFF4 scaffold
@en
P2093
P2860
P356
P1476
HIV-1 Tat recruits transcripti ...... along a flexible AFF4 scaffold
@en
P2093
Anna Nowak
Avi J Samelson
Heather Upton
Huasong Lu
Katherine Bao
Nevan J Krogan
Qiang Zhou
Seemay Chou
P2860
P304
P356
10.1073/PNAS.1216971110
P407
P577
2012-12-18T00:00:00Z