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The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

http://www.wikidata.org/entity/Q35206311

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A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions Candidate prognostic markers in breast cancer: focus on extracellular proteases and their inhibitors Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10)Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy A disintegrin and metalloproteinase-12 (ADAM12): function, roles in disease progression, and clinical implications Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance.Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities A disintegrin and metalloproteinase 9 is involved in ectodomain shedding of receptor-binding cancer antigen expressed on SiSo cells.ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis.An association study on ADAM10 promoter polymorphisms and atherosclerotic cerebral infarction in a Chinese population.N-glycosylation regulates ADAM8 processing and activation Genome wide analysis of chromosomal alterations in oral squamous cell carcinomas revealed over expression of MGAM and ADAM9.miR-126&126* restored expressions play a tumor suppressor role by directly regulating ADAM9 and MMP7 in melanoma.The effect of disintegrin-metalloproteinase ADAM9 in gastric cancer progression High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation.ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells.Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells ADAM15 Is Functionally Associated with the Metastatic Progression of Human Bladder Cancer Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain.The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells.An essential role of metalloprotease-disintegrin ADAM12 in triple-negative breast cancer ADAM12 expression predicts clinical outcome in estrogen receptor-positive breast cancer.Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7)Effects of ADAM10 upregulation on progression, migration, and prognosis of nasopharyngeal carcinoma.Fluorescent Analogue of Batimastat Enables Imaging of α-Secretase in Living Cells miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells.NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17).Osteoactivin (GPNMB) ectodomain protein promotes growth and invasive behavior of human lung cancer cells.ADAM17 in tumor associated leukocytes regulates inflammatory mediators and promotes mammary tumor formation.Metalloproteinase-disintegrin ADAM12 is associated with a breast tumor-initiating cell phenotype.Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation.Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells A disintegrin and metalloproteinases 10 and 17 modulate the immunogenicity of glioblastoma-initiating cells.ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis.

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The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

http://www.wikidata.org/entity/Q35206311

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2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

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The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

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type

label

The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

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The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

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The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

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The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

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Clinical Proteomics

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The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

@en

P2093

Aisling Pierce

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John Crown

http://www.w3.org/2001/XMLSchema#string

Michael J Duffy

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Sumainizah Sukor

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Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.

ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma

Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF

Expression of ADAM-9 mRNA and protein in human breast cancer

ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer

Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans

The EGF receptor family: spearheading a merger of signaling and therapeutics

The ADAM metalloproteinases

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10.1186/1559-0275-8-9

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1

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Norma O'Donovan

Patricia M McGowan

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2011-06-09T00:00:00Z

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51637861

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1027268849

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