Astrocytes from familial and sporadic ALS patients are toxic to motor neurons - Wikidata - wikimedia - TriplyDB

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

http://www.wikidata.org/entity/Q35206666

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Different human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in mice Human Stem Cell-Derived Astrocytes: Specification and Relevance for Neurological Disorders Adeno Associated Viral Vector Delivered RNAi for Gene Therapy of SOD1 Amyotrophic Lateral Sclerosis Quo vadis motor neuron disease?Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles Neuroinflammation in motor neuron disease Elusive roles for reactive astrocytes in neurodegenerative diseases Astrocytes conspire with neurons during progression of neurological disease Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis Glia: an emerging target for neurological disease therapy Induced pluripotent stem cells from ALS patients for disease modeling Microglia centered pathogenesis in ALS: insights in cell interconnectivity Therapeutic neuroprotective agents for amyotrophic lateral sclerosis Blood-CNS Barrier Impairment in ALS patients versus an animal model Stem cells in the nervous system A large animal model of spinal muscular atrophy and correction of phenotype.Structural switching of Cu,Zn-superoxide dismutases at loop VI: insights from the crystal structure of 2-mercaptoethanol-modified enzyme Therapeutic applications of mesenchymal stem cells for amyotrophic lateral sclerosis.Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS A perspective on stem cell modeling of amyotrophic lateral sclerosis Emerging mechanisms of molecular pathology in ALS RNA-targeted Therapeutics for ALS Prion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis A novel acylaminoimidazole derivative, WN1316, alleviates disease progression via suppression of glial inflammation in ALS mouse model Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm.Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis.Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model.Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo.Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration.Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model.Human glial progenitor engraftment and gene expression is independent of the ALS environment Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis.

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P2860

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

http://www.wikidata.org/entity/Q35206666

description

2011 nî lūn-bûn

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2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

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Nature Biotechnology

P1476

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

@en

P2093

Amanda M Haidet-Phillips

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Amy Eagle

http://www.w3.org/2001/XMLSchema#string

Anja Kammesheidt

http://www.w3.org/2001/XMLSchema#string

Ashley Christensen

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Ashley Frakes

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Brian K Kaspar

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Carlos J Miranda

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Jerry R Mendell

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Kathrin Meyer

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Kevin D Foust

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P2860

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function

Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

Directed differentiation of embryonic stem cells into motor neurons

Mechanisms underlying inflammation in neurodegeneration

ALS: a disease of motor neurons and their nonneuronal neighbors

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

Onset and progression in inherited ALS determined by motor neurons and microglia

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.

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824-828

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10.1038/NBT.1957

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9

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29

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2011-08-10T00:00:00Z

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51563186

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21832997

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amyotrophic lateral sclerosis

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3170425

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