Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of schizophrenia - Wikidata - wikimedia - TriplyDB

Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of schizophrenia

Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of schizophrenia

http://www.wikidata.org/entity/Q35207454

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Dopamine-prolactin pathway potentially contributes to the schizophrenia and type 2 diabetes comorbidity Social behavior in a genetic model of dopamine dysfunction at different neurodevelopmental time points.BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies Anhedonia, avolition, and anticipatory deficits: assessments in animals with relevance to the negative symptoms of schizophrenia Selective overexpression of dopamine D3 receptors in the striatum disrupts motivation but not cognition.Dissociation of hedonic reaction to reward and incentive motivation in an animal model of the negative symptoms of schizophrenia Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation.Modeling motivational deficits in mouse models of schizophrenia: behavior analysis as a guide for neuroscience.Amotivation in schizophrenia: integrated assessment with behavioral, clinical, and imaging measures.Serotonin and dopamine receptors in motivational and cognitive disturbances of schizophrenia Apathy but not diminished expression in schizophrenia is associated with discounting of monetary rewards by physical effort.Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area.The 4th Schizophrenia International Research Society Conference, 5-9 April 2014, Florence, Italy: a summary of topics and trends.A novel strategy for dissecting goal-directed action and arousal components of motivated behavior with a progressive hold-down task Improving temporal cognition by enhancing motivation.Using human brain imaging studies as a guide toward animal models of schizophrenia.Schizophrenia in translation: dissecting motivation in schizophrenia and rodents.Dopamine D₂-Like Receptors and Behavioral Economics of Food Reinforcement.The Behavioral Neuroscience of Motivation: An Overview of Concepts, Measures, and Translational Applications The effects of pharmacological modulation of the serotonin 2C receptor on goal-directed behavior in mice The impact of motivation on cognitive performance in an animal model of the negative and cognitive symptoms of schizophrenia.Agomelatine for Depression in Schizophrenia: A Case-Series Measuring reinforcement learning and motivation constructs in experimental animals: relevance to the negative symptoms of schizophrenia.A novel aminotetralin-type serotonin (5-HT) 2C receptor-specific agonist and 5-HT2A competitive antagonist/5-HT2B inverse agonist with preclinical efficacy for psychoses.Cognitive states influence dopamine-driven aberrant learning in Parkinson's disease.Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology.Neural substrates underlying effort, time, and risk-based decision making in motivated behavior.Insights About Striatal Circuit Function and Schizophrenia From a Mouse Model of Dopamine D2 Receptor Upregulation.Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels.LPS-induced cortical kynurenic acid and neurogranin-NFAT signaling is associated with deficits in stimulus processing during Pavlovian conditioning.An Interaction between Serotonin Receptor Signaling and Dopamine Enhances Goal-Directed Vigor and Persistence in Mice.Conflict acts as an implicit cost in reinforcement learning.Reduced activity at the 5-HT(2C) receptor enhances reversal learning by decreasing the influence of previously non-rewarded associations.Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research.The Effects of Cariprazine and Aripiprazole on PCP-Induced Deficits on Attention Assessed in the 5-Choice Serial Reaction Time Task.Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice.

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Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of schizophrenia

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J.BIOPSYCH.2011.01.012

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Biological Psychiatry

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Christoph Kellendonk

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Eleanor H Simpson

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Eric R Kandel

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Olga Lipatova

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Vanessa Richards

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P2860

Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies

RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity

Impaired timing precision produced by striatal D2 receptor overexpression is mediated by cognitive and motivational deficits

D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons

Control of memory formation through regulated expression of a CaMKII transgene

Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function

Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests.

Role of 5-HT(2C) receptors in the control of central dopamine function.

Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens.

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