Mitochondrial deoxynucleotide pool sizes in mouse liver and evidence for a transport mechanism for thymidine monophosphate.
about
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondriaThe human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transportersModeling cellular compartmentation in one-carbon metabolismNucleotide salvage deficiencies, DNA damage and neurodegenerationAn analysis of enzyme kinetics data for mitochondrial DNA strand termination by nucleoside reverse transcription inhibitorsEnzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replicationLimited dCTP availability accounts for mitochondrial DNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance.Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.Transgenic cardiac-targeted overexpression of human thymidylate kinaseMembrane association of mitochondrial DNA facilitates base excision repair in mammalian mitochondria.Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency.C-terminal extension of the yeast mitochondrial DNA polymerase determines the balance between synthesis and degradation.The role of the mitochondrial glycine cleavage complex in the metabolism and virulence of the protozoan parasite Leishmania majorOnset and organ specificity of Tk2 deficiency depends on Tk1 down-regulation and transcriptional compensation.Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice.The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stressNucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site.Nucleoside triphosphate pool asymmetry in mammalian mitochondriaHeart mitochondrial TTP synthesis and the compartmentalization of TMP.A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cellsCorrelated tissue expression of genes of cytoplasmic and mitochondrial nucleotide metabolisms in normal tissues is disrupted in transformed tissuesTrace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase gamma replication fidelity.Ribonucleotide reductase association with mammalian liver mitochondria.Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient miceMurine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation.Cardiac-targeted transgenic mutant mitochondrial enzymes: mtDNA defects, antiretroviral toxicity and cardiomyopathy.Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ10 deficiency.Deoxyribonucleotides as genetic and metabolic regulatorsKinetic investigation of the inhibitory effect of gemcitabine on DNA polymerization catalyzed by human mitochondrial DNA polymerase.Quantitation of cellular deoxynucleoside triphosphates.Mitochondrial thymidine kinase and the enzymatic network regulating thymidine triphosphate pools in cultured human cells.p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage.Deoxyribonucleotide metabolism in cycling and resting human fibroblasts with a missense mutation in p53R2, a subunit of ribonucleotide reductase.Deoxynucleoside salvage enzymes and tissue specific mitochondrial DNA depletion.Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency.Metabolic interrelations within guanine deoxynucleotide pools for mitochondrial and nuclear DNA maintenance.Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML.Plants salvage deoxyribonucleosides in mitochondria.
P2860
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P2860
Mitochondrial deoxynucleotide pool sizes in mouse liver and evidence for a transport mechanism for thymidine monophosphate.
description
2006 nî lūn-bûn
@nan
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Mitochondrial deoxynucleotide ...... m for thymidine monophosphate.
@ast
Mitochondrial deoxynucleotide ...... m for thymidine monophosphate.
@en
type
label
Mitochondrial deoxynucleotide ...... m for thymidine monophosphate.
@ast
Mitochondrial deoxynucleotide ...... m for thymidine monophosphate.
@en
prefLabel
Mitochondrial deoxynucleotide ...... m for thymidine monophosphate.
@ast
Mitochondrial deoxynucleotide ...... m for thymidine monophosphate.
@en
P2093
P2860
P356
P1476
Mitochondrial deoxynucleotide ...... m for thymidine monophosphate.
@en
P2093
Luca Nicolosi
Paola Ferraro
Peter Reichard
Vera Bianchi
P2860
P304
18586-18591
P356
10.1073/PNAS.0609020103
P407
P577
2006-11-21T00:00:00Z