Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR
about
Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblastsLoss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging AgentsThe Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis.Increased Nek1 expression in renal cell carcinoma cells is associated with decreased sensitivity to DNA-damaging treatmentRas/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress responseTranscriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases.New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicingExpression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney diseaseGiardia lamblia Nek1 and Nek2 kinases affect mitosis and excystation.NEK8 regulates DNA damage-induced RAD51 foci formation and replication fork protectionNek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization.Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies.Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression.Beyond ATM: the protein kinase landscape of the DNA damage response.Cell cycle regulation by the NEK family of protein kinases.TDP-43/FUS in motor neuron disease: Complexity and challenges.Nek family of kinases in cell cycle, checkpoint control and cancer.Compound heterozygous NEK1 variants in two siblings with oral-facial-digital syndrome type II (Mohr syndrome).Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability.ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion.Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza.Identification of the proteome complement of humanTLK1 reveals it binds and phosphorylates NEK1 regulating its activity.The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects.
P2860
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P2860
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Nek1 kinase functions in DNA d ...... way independent of ATM and ATR
@ast
Nek1 kinase functions in DNA d ...... way independent of ATM and ATR
@en
type
label
Nek1 kinase functions in DNA d ...... way independent of ATM and ATR
@ast
Nek1 kinase functions in DNA d ...... way independent of ATM and ATR
@en
prefLabel
Nek1 kinase functions in DNA d ...... way independent of ATM and ATR
@ast
Nek1 kinase functions in DNA d ...... way independent of ATM and ATR
@en
P2093
P2860
P356
P1433
P1476
Nek1 kinase functions in DNA d ...... way independent of ATM and ATR
@en
P2093
Chi-Fen Chen
Daniel J Riley
Phang-Lang Chen
Yumay Chen
P2860
P304
P356
10.4161/CC.10.4.14814
P577
2011-02-15T00:00:00Z