Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR - Wikidata - wikimedia - TriplyDB

Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR

Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR

http://www.wikidata.org/entity/Q35215434

about

Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis.Increased Nek1 expression in renal cell carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases.New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing Expression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney disease Giardia lamblia Nek1 and Nek2 kinases affect mitosis and excystation.NEK8 regulates DNA damage-induced RAD51 foci formation and replication fork protection Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization.Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies.Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression.Beyond ATM: the protein kinase landscape of the DNA damage response.Cell cycle regulation by the NEK family of protein kinases.TDP-43/FUS in motor neuron disease: Complexity and challenges.Nek family of kinases in cell cycle, checkpoint control and cancer.Compound heterozygous NEK1 variants in two siblings with oral-facial-digital syndrome type II (Mohr syndrome).Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability.ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion.Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza.Identification of the proteome complement of humanTLK1 reveals it binds and phosphorylates NEK1 regulating its activity.The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects.

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Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR

http://www.wikidata.org/entity/Q35215434

description

2011 nî lūn-bûn

@nan

2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Nek1 kinase functions in DNA d ...... way independent of ATM and ATR

@ast

Nek1 kinase functions in DNA d ...... way independent of ATM and ATR

@en

type

label

Nek1 kinase functions in DNA d ...... way independent of ATM and ATR

@ast

Nek1 kinase functions in DNA d ...... way independent of ATM and ATR

@en

prefLabel

Nek1 kinase functions in DNA d ...... way independent of ATM and ATR

@ast

Nek1 kinase functions in DNA d ...... way independent of ATM and ATR

@en

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Nek1 kinase functions in DNA d ...... way independent of ATM and ATR

@en

P2093

Chi-Fen Chen

http://www.w3.org/2001/XMLSchema#string

Daniel J Riley

http://www.w3.org/2001/XMLSchema#string

Phang-Lang Chen

http://www.w3.org/2001/XMLSchema#string

Yumay Chen

http://www.w3.org/2001/XMLSchema#string

P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1

The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing

Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1

NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice

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655-663

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scholarly article

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10.4161/CC.10.4.14814

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4

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10

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