Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
about
The CK1 Family: Contribution to Cellular Stress Response and Its Role in CarcinogenesisParvovirus minute virus of mice induces a DNA damage response that facilitates viral replicationChk1 suppressed cell deathMelatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathwaysA mouse model of ATR-Seckel shows embryonic replicative stress and accelerated agingCritical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpointHuman Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpointCoupling of human circadian and cell cycles by the timeless protein.Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophagesA genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activationDNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domainsThe F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stressTumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activationDTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpointCEP152 is a genome maintenance protein disrupted in Seckel syndromeInteraction between human MCM7 and Rad17 proteins is required for replication checkpoint signalingChk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signallingNovel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpointsDNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free systemActivation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firingActivation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damageDisruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1BRCT domain-containing protein PTIP is essential for progression through mitosisPhosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damageMethylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinasesHuman Claspin works with BRCA1 to both positively and negatively regulate cell proliferationThe Werner syndrome protein: linking the replication checkpoint response to genome stabilityTargeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugsMore than blood, a novel gene required for mammalian postimplantation developmentDifferentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activityClaspin promotes normal replication fork rates in human cellsG2E3 is a dual function ubiquitin ligase required for early embryonic developmentImplication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage responseThe combined status of ATM and p53 link tumor development with therapeutic response
P2860
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P2860
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
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2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
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Chk1 is an essential kinase th ...... e G(2)/M DNA damage checkpoint
@ast
Chk1 is an essential kinase th ...... e G(2)/M DNA damage checkpoint
@en
Chk1 is an essential kinase th ...... e G(2)/M DNA damage checkpoint
@nl
type
label
Chk1 is an essential kinase th ...... e G(2)/M DNA damage checkpoint
@ast
Chk1 is an essential kinase th ...... e G(2)/M DNA damage checkpoint
@en
Chk1 is an essential kinase th ...... e G(2)/M DNA damage checkpoint
@nl
prefLabel
Chk1 is an essential kinase th ...... e G(2)/M DNA damage checkpoint
@ast
Chk1 is an essential kinase th ...... e G(2)/M DNA damage checkpoint
@en
Chk1 is an essential kinase th ...... e G(2)/M DNA damage checkpoint
@nl
P2093
P2860
P921
P1433
P1476
Chk1 is an essential kinase th ...... e G(2)/M DNA damage checkpoint
@en
P2093
L A Donehower
S Carattini-Rivera
S J Elledge
P2860
P304
P407
P577
2000-06-15T00:00:00Z