Microtubules, microtubule-interfering agents and apoptosis.
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Preadministration of High-Dose Salicylates, Suppressors of NF- B Activation, May Increase the Chemosensitivity of Many Cancers: An Example of Proapoptotic Signal Modulation TherapyInhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisonsRole of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosisRACK1 and CIS mediate the degradation of BimEL in cancer cellsMicrotubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied.Paclitaxel targets VEGF-mediated angiogenesis in ovarian cancer treatmentTarget identification by image analysisIn vitro and in vivo prostate cancer metastasis and chemoresistance can be modulated by expression of either CD44 or CD147Induction of tumor cell death through targeting tubulin and evoking dysregulation of cell cycle regulatory proteins by multifunctional cinnamaldehydesA synthetic podophyllotoxin derivative exerts anti-cancer effects by inducing mitotic arrest and pro-apoptotic ER stress in lung cancer preclinical modelsA novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathwayThe calpain inhibitor MDL28170 induces the expression of apoptotic markers in Leishmania amazonensis promastigotesThe novel tubulin polymerization inhibitor MHPT exhibits selective anti-tumor activity against rhabdomyosarcoma in vitro and in vivoMutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathwayPaclitaxel resistance in untransformed human mammary epithelial cells is associated with an aneuploidy-prone phenotype.Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane.The doublecortin-related gene zyg-8 is a microtubule organizer in Caenorhabditis elegans neuronsPMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells.Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP.Antitumor activity of new enantiopure pybox-ruthenium complexes.Molecular interaction of TPPP with PrP antagonized the CytoPrP-induced disruption of microtubule structures and cytotoxicityTubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cellsA novel synthetic analog of 5, 8-disubstituted quinazolines blocks mitosis and induces apoptosis of tumor cells by inhibiting microtubule polymerization.Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis.Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinibBUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD).Blocking TRAIL-DR5 signaling with soluble DR5 alleviates acute kidney injury in a severely burned mouse model.Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.Effects of cell cycle inhibitors on tau phosphorylation in N2aTau3R cells.Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazoleAnti-MUC1 monoclonal antibody (C595) and docetaxel markedly reduce tumor burden and ascites, and prolong survival in an in vivo ovarian cancer model.A tubulin binding peptide targets glioma cells disrupting their microtubules, blocking migration, and inducing apoptosis.Synthesis and in vitro evaluation of 3h-pyrrolo[3,2-f]-quinolin-9-one derivatives that show potent and selective anti-leukemic activityNovel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluationRemarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain.Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model.Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents.DAT-230, a novel microtubule inhibitor, exhibits potent anti-tumor activity by inducing G2/M phase arrest, apoptosis in vitro and perfusion decrease in vivo to HT-1080.
P2860
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P2860
Microtubules, microtubule-interfering agents and apoptosis.
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Microtubules, microtubule-interfering agents and apoptosis.
@ast
Microtubules, microtubule-interfering agents and apoptosis.
@en
type
label
Microtubules, microtubule-interfering agents and apoptosis.
@ast
Microtubules, microtubule-interfering agents and apoptosis.
@en
prefLabel
Microtubules, microtubule-interfering agents and apoptosis.
@ast
Microtubules, microtubule-interfering agents and apoptosis.
@en
P356
P1433
P1476
Microtubules, microtubule-interfering agents and apoptosis
@en
P2093
Mollinedo F
P2888
P304
P356
10.1023/A:1025513106330
P577
2003-10-01T00:00:00Z
P6179
1035156156