about
Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implicationsCytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapyInvolvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cellsLipid raft-targeted therapy in multiple myeloma.Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils.Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions.Antitumor alkyl ether lipid edelfosine: tissue distribution and pharmacokinetic behavior in healthy and tumor-bearing immunosuppressed mice.Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH(3) (edelfosine), a proapoptotic agent in tumor cells.Induction of apoptosis in human mitogen-activated peripheral blood T-lymphocytes by the ether phospholipid ET-18-OCH3: involvement of the Fas receptor/ligand system.Microtubules, microtubule-interfering agents and apoptosis.Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy.Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy.Lipid rafts and Fas/CD95 signaling in cancer chemotherapy.Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine.Lipid rafts as major platforms for signaling regulation in cancer.Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes.Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling.Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy.The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death.Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells.Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin.Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxin.In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts.Triggers and signaling cross-talk controlling cell death commitment.Lipid raft connection between extrinsic and intrinsic apoptotic pathways.Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis.Apoptotic mechanisms are involved in the death of Strongyloides venezuelensis after triggering of nitric oxide.Antitumor activity of Lepidium latifolium and identification of the epithionitrile 1-cyano-2,3-epithiopropane as its major active component.Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.Isolation of Lipid Rafts Through Discontinuous Sucrose Gradient Centrifugation and Fas/CD95 Death Receptor Localization in Raft Fractions.Lipid rafts, death receptors and CASMERs: new insights for cancer therapy.Effects of the anti-neoplastic agent ET-18-OCH3 and some analogs on the biophysical properties of model membranes.C-Fos is not essential for apoptosis.Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.Fluorescent Phenylpolyene Analogues of the Ether Phospholipid Edelfosine for the Selective Labeling of Cancer Cells
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description
hulumtuese
@sq
researcher
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wetenschapper
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հետազոտող
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name
Consuelo Gajate
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Consuelo Gajate
@en
Consuelo Gajate
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Consuelo Gajate
@nl
Consuelo Gajate
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type
label
Consuelo Gajate
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Consuelo Gajate
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Consuelo Gajate
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Consuelo Gajate
@nl
Consuelo Gajate
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prefLabel
Consuelo Gajate
@ast
Consuelo Gajate
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Consuelo Gajate
@es
Consuelo Gajate
@nl
Consuelo Gajate
@sl
P106
P1153
6603017549
P21
P31
P496
0000-0003-0604-6459