B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis - Wikidata - wikimedia - TriplyDB

B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis

B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis

http://www.wikidata.org/entity/Q35222002

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Pharmacotherapy of systemic sclerosis Current perspectives on the immunopathogenesis of systemic sclerosis Rituximab in diffuse cutaneous systemic sclerosis: should we be using it today?Immunotherapeutic mechanisms of anti-CD20 monoclonal antibodies.B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial.B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals.Systemic Sclerosis-Associated Interstitial Lung Disease: Lessons from Clinical Trials, Outcome Measures, and Future Study Design.Prolonged effects of short-term anti-CD20 B cell depletion therapy in murine systemic lupus erythematosus.B cells and transplantation: an educational resource.B cell depletion therapy exacerbates murine primary biliary cirrhosis IL-10-producing regulatory B10 cells inhibit intestinal injury in a mouse model Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression.Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice.Systemic sclerosis: a prototypic multisystem fibrotic disorder.Transient depletion of B cells in young mice results in activation of regulatory T cells that inhibit development of autoimmune disease in adults Mechanisms of Disease: the role of immune cells in the pathogenesis of systemic sclerosis.CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma.Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice.Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice.Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation.Efficacy of rapamycin in scleroderma: a case study.B cells and immunological tolerance.Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets.Assessment of liver stiffness in patients with HCV and mixed cryoglobulinemia undergoing rituximab treatment.The role of B cells in systemic sclerosis.B Cell Homeostasis and Functional Properties Are Altered in an Hypochlorous Acid-Induced Murine Model of Systemic Sclerosis.The pathogenesis of systemic sclerosis revisited.B lymphocytes and B-cell activating factor promote collagen and profibrotic markers expression by dermal fibroblasts in systemic sclerosis B-lymphocyte effector functions in health and disease.Capturing the heterogeneity in systemic sclerosis with genome-wide expression profiling.Scleroderma therapy: clinical overview of current trends and future perspective.Abnormal B lymphocyte activation and function in systemic sclerosis.Cytokines in the immunopathology of systemic sclerosis.B lymphocytes in systemic sclerosis: Abnormalities and therapeutic targets.Strategy for treatment of fibrosis in systemic sclerosis: Present and future.

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B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis

http://www.wikidata.org/entity/Q35222002

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2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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B-lymphocyte depletion reduces ...... e model for systemic sclerosis

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The American Journal of Pathology

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B-lymphocyte depletion reduces ...... e model for systemic sclerosis

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Jean-David Bouaziz

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Junji Uchida

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Kazuhiko Takehara

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Koichi Yanaba

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Manabu Fujimoto

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Mayuka Horikawa

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Shinichi Sato

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Takashi Matsushita

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Thomas F Tedder

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Yasuhito Hamaguchi

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P2860

CD20 (pan-B cell antigen) expression on bone marrow-derived T cells

Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes.

Autoantibody reactive with three classes of RNA polymerases in sera from patients with systemic sclerosis

Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts

CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse

B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse.

Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma.

Fibrotic disease and the T(H)1/T(H)2 paradigm.

Prospects for B-cell-targeted therapy in autoimmune disease.

The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system.

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Kazuhiro Komura

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6852848

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