Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice.
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Establishment of lal-/- myeloid lineage cell line that resembles myeloid-derived suppressive cellsApi6/AIM/Spα/CD5L overexpression in alveolar type II epithelial cells induces spontaneous lung adenocarcinomaTrapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation.Critical roles of lysosomal acid lipase in myelopoiesis.Myeloid-derived suppressor cells are involved in lysosomal acid lipase deficiency-induced endothelial cell dysfunctions.Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophagesInducible transgenes under the control of the hCD68 promoter identifies mouse macrophages with a distribution that differs from the F4/80 - and CSF-1R-expressing populations.Gene profile of myeloid-derived suppressive cells from the bone marrow of lysosomal acid lipase knock-out mice.Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells.Transgenic expression of nonclassically secreted FGF suppresses kidney repair.Activation of mTOR pathway in myeloid-derived suppressor cells stimulates cancer cell proliferation and metastasis in lal(-/-) miceOverexpression of dominant negative peroxisome proliferator-activated receptor-γ (PPARγ) in alveolar type II epithelial cells causes inflammation and T-cell suppression in the lung.Matrix metalloproteinase 12 overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis.Myeloid-specific expression of human lysosomal acid lipase corrects malformation and malfunction of myeloid-derived suppressor cells in lal-/- miceInhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis.Systems genetic analysis of multivariate response to iron deficiency in mice.PPARs in alveolar macrophage biology.Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?Dual-promoter lentiviral system allows inducible expression of noxious proteins in macrophages.Autophagy Is Dispensable for Macrophage-Mediated Lipid Homeostasis in Adipose TissueCritical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis.Myeloid-specific expression of Api6/AIM/Sp alpha induces systemic inflammation and adenocarcinoma in the lungCritical roles of lysosomal acid lipase in T cell development and function.Trends in the Evolution of Snake Toxins Underscored by an Integrative Omics Approach to Profile the Venom of the Colubrid Phalotris mertensi.Matrix metalloproteinase 12 overexpression in lung epithelial cells plays a key role in emphysema to lung bronchioalveolar adenocarcinoma transition.Critical role of the mTOR pathway in development and function of myeloid-derived suppressor cells in lal-/- mice.Hepatocyte-Specific Expression of Human Lysosome Acid Lipase Corrects Liver Inflammation and Tumor Metastasis in lal(-/-) Mice.Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages.Lung Epithelial Cell-Specific Expression of Human Lysosomal Acid Lipase Ameliorates Lung Inflammation and Tumor Metastasis in Lipa(-/-) MiceBlood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammationA novel transgenic mouse model of lysosomal storage disorderLysosomal acid lipase over-expression disrupts lamellar body genesis and alveolar structure in the lung.CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report.Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis.Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production.Myeloid-specific expression of Stat3C results in conversion of bone marrow mesenchymal stem cells into alveolar type II epithelial cells in the lung.A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice
P2860
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P2860
Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice.
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Macrophage-specific expression ...... nic phenotypes in lal-/- mice.
@ast
Macrophage-specific expression ...... nic phenotypes in lal-/- mice.
@en
type
label
Macrophage-specific expression ...... nic phenotypes in lal-/- mice.
@ast
Macrophage-specific expression ...... nic phenotypes in lal-/- mice.
@en
prefLabel
Macrophage-specific expression ...... nic phenotypes in lal-/- mice.
@ast
Macrophage-specific expression ...... nic phenotypes in lal-/- mice.
@en
P2093
P2860
P1476
Macrophage-specific expression ...... enic phenotypes in lal-/- mice
@en
P2093
Amanda White
Xuemei Lian
P2860
P304
P356
10.2353/AJPATH.2006.051327
P407
P577
2006-09-01T00:00:00Z