APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor. - Wikidata - wikimedia - TriplyDB

APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.

APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.

http://www.wikidata.org/entity/Q35234727

about

Adiponectin signaling and function in insulin target tissues Cross-Talk between Adiponectin and IGF-IR in Breast Cancer The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins Loss-of-Function Mutations in APPL1 in Familial Diabetes Mellitus Adiponectin and insulin cross talk: the microvascular connection.Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling.Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer's Disease.Tissue-specific insulin signaling in the regulation of metabolism and aging.Beclin 1 regulates growth factor receptor signaling in breast cancer.APPL1-Mediating Leptin Signaling Contributes to Proliferation and Migration of Cancer Cells.Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease.Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts.Adiponectin, the past two decades.Potential Neuroprotective Effects of Adiponectin in Alzheimer's Disease.Cerebral insulin, insulin signaling pathway, and brain angiogenesis.APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes.Comparative proteomics of paired vocal fold and oral mucosa fibroblasts.The impact of insulin resistance on the kidney and vasculature.Adiponectin as a Potential Therapeutic Target for Prostate Cancer.APPL1 is a multifunctional endosomal signaling adaptor protein.Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease.OCDD: an obesity and co-morbid disease database.Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms.Hepatic DsbA-L protects mice from diet-induced hepatosteatosis and insulin resistance.α5β1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration.Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease.Adiponectin-Resistance in Obesity.Evidence for decreased expression of APPL1 associated with reduced insulin and adiponectin receptors expression in PCOS patients.Alternative splicing variant of the scaffold protein APPL1 suppresses hepatic adiponectin signaling and function.

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P2860

APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.

http://www.wikidata.org/entity/Q35234727

description

2014 nî lūn-bûn

@nan

2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

APPL1 potentiates insulin sens ...... RS1/2 to the insulin receptor.

@ast

APPL1 potentiates insulin sens ...... RS1/2 to the insulin receptor.

@en

type

label

APPL1 potentiates insulin sens ...... RS1/2 to the insulin receptor.

@ast

APPL1 potentiates insulin sens ...... RS1/2 to the insulin receptor.

@en

prefLabel

APPL1 potentiates insulin sens ...... RS1/2 to the insulin receptor.

@ast

APPL1 potentiates insulin sens ...... RS1/2 to the insulin receptor.

@en

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P356

J.CELREP.2014.04.006

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APPL1 potentiates insulin sens ...... RS1/2 to the insulin receptor.

@en

P2093

Amanda K Galan

http://www.w3.org/2001/XMLSchema#string

Bekke M Holmes

http://www.w3.org/2001/XMLSchema#string

Changhua Wang

http://www.w3.org/2001/XMLSchema#string

Chuxia Deng

http://www.w3.org/2001/XMLSchema#string

Cuiling Li

http://www.w3.org/2001/XMLSchema#string

Feng Dong

http://www.w3.org/2001/XMLSchema#string

Feng Liu

http://www.w3.org/2001/XMLSchema#string

Jiyoon Ryu

http://www.w3.org/2001/XMLSchema#string

Lauren B Sloane

http://www.w3.org/2001/XMLSchema#string

Lijun Zhou

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation

Mediation of the DCC apoptotic signal by DIP13 alpha

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

The insulin signaling system

Critical nodes in signalling pathways: insights into insulin action

Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling.

Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells

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1227-1238

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scholarly article

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10.1016/J.CELREP.2014.04.006

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4

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7

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Ralph A DeFronzo

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2014-05-10T00:00:00Z

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262230255

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24813896

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4380268

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